Evidence map›Paper›PMID 40108597›Full record

ArticleBMC pediatrics2025

Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients.

Lanlan Huang, Xinjia Liu, Songyang Li, Yongjie Liu, Weijian Chen, Yana Li, Hongyan Peng, Xiangyu Wang, Peiwen Xiong, Qinglan Yang and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Lanlan Huang *The School of Pediatrics, Hengyang Medical School, University of South China, Changsha, 410007, China.
Xinjia Liu *The School of Pediatrics, Hengyang Medical School, University of South China, Changsha, 410007, China.
Songyang LiThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Yongjie LiuThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Weijian ChenDepartment of Pathology, Hunan Children's Hospital, Changsha, 410000, China.
Yana LiThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Hongyan PengThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Xiangyu WangThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Peiwen XiongThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Qinglan YangThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Shuting WuThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, 410007, China.
Ling CheDepartment of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100853, China. cheling309@126.com.
Hongmei ZhaoDepartment of Digestive Nutrition, Hunan Children's Hospital, Changsha, 410000, China. marge_zh@sina.com.
Yafei DengThe School of Pediatrics, Hengyang Medical School, University of South China, Changsha, 410007, China. yafeideng01@sina.com.

Funding

the Hunan Provincial Natural Science Foundation of China 2023JJ30320the National Natural Science Foundation of China 32100490the National Natural Science Foundation of China 81703521the National Natural Science Foundation of China 81900055the Natural Science Foundation of Changsha, Hunan Province kq2208090
6 · The paper itself

Abstract

backgroundHistologically, our understanding of intestinal polyps remains limited in scope, particularly regarding the diverse subtypes observed in pediatric patients. To enhance our comprehension, three different polyp subtypes including solitary juvenile polyps (SJPs), juvenile polyposis syndrome (JPS)-related polyps, and Peutz‒Jeghers syndrome (PJS)-related polyps were investigated.

methodsThis study used advanced multiplex immunohistochemistry (mIHC) technology to analyze polyps comprising 4 SJP, 4 JPS and 4 PJS polyps from 12 individual patients who underwent colonoscopies or radical surgical procedures. subtypes.

resultsThese mIHC analyses revealed some differences among these polyp subtypes. PJS-related polyps, specifically, displayed epithelial dysplasia with dendritic gland hyperplasia and distinct villous structures adorned with finger-like projections on their surfaces. In contrast, SJP and JPS polyps exhibited cystic glandular dilation, with their surfaces lined with continuous but eroded epithelia. Furthermore, PJS polyps had an abundance of microvessels and thick smooth muscle fibers, whereas SJP and JPS polyps were characterized by lymphoid follicle-like structures.

conclusionsThese findings not only deepen our structural understanding of various intestinal polyp subtypes but also offer valuable insights that may inform the diagnosis of patients with these conditions.

Indexed as

Intestinal PolyposisIntestinal PolypsPeutz-Jeghers SyndromeAdolescentChildChild, PreschoolColonoscopyFemaleHumansImmunohistochemistryMaleNeoplastic Syndromes, HereditaryCystic glandular dilationEpithelial dysplasiaMultiplex immunohistochemistryPediatric intestinal polyps

Identifiers

PMID40108597
PMCPMC11921745

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