Evidence map›Paper›PMID 40108561›Full record

ArticleBMC pediatrics2025

Gut microbiota signatures in food allergy children without and with malnutrition: a cross-sectional study.

Xiaojiao Zhang, Hengying Chen, Yiyuan Wang, Qiujin Xu, Xinzu Qiu, Li Cheng, Qizhi Xiao, Yanhong Liu, Jianduan Zhang, Hongzhong Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaojiao Zhang *Department of Child Health Care, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China.
Hengying Chen *Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yiyuan WangDepartment of Child Health Care, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China.
Qiujin XuCuixiang Community Health Center, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China.
Xinzu QiuDepartment of Child Health Care, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China.
Li ChengDepartment of Child Health Care, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China.
Qizhi XiaoDepartment of Medical Genetics and Prenatal Diagnosis, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China.
Yanhong LiuDepartment of Research and Development, BGI Precision Nutrition (Shenzhen) Technology Co., Ltd, Shenzhen, Guangdong, China.
Jianduan ZhangDepartment of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Hongzhong ZhangZhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China. qdzhz@126.com.
Hongyuan WuDepartment of Child Health Care, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, China. whypq13@126.com.

Funding

the Medical and Health Science and Technology Program of Zhuhai City No.2220004000337the Medical and Health Science and Technology Program of Zhuhai City (Major Project) No. ZH22036201210183PWC
6 · The paper itself

Abstract

backgroundAltered gut microbiota (GM) profiles have been documented in children with food allergies (FA) and experiencing malnutrition. This study explored the GM composition in children with FA across varying degrees of malnutrition including those without malnutrition and those with different severity levels.

methodsFresh faecal samples were collected from 120 children aged 1-6 years, including 40 FA children with adequate weight (FANM), 40 FA children with malnutrition (FAM), and 40 healthy controls. The hypervariable region of the 16 S rDNA gene was subsequently sequenced to assess bacterial communities.

resultsCompared with healthy controls, the FANM group displayed a greater increase in the alpha diversity index. The FAM group exhibited an increase in seven genera, including Alistipes and Parabacteroides, compared to the control group, whereas nine genera were enriched in the FANM group. An analysis of clinical characteristics revealed a positive correlation between the relative abundance of the genus Faecalibacterium and the total IgE level. Fourteen pivotal microbial markers demonstrated substantial classification potential (AUC: 89.86%, 95% CI: 76.40-99.73% for FAM; AUC: 88.92%, 95% CI: 73.58-99.65% for FANM).

conclusionFA children exhibit distinct GM profiles depending on the presence of malnutrition, which suggests the need for tailored microbiota-targeted therapies.

Indexed as

Child Nutrition DisordersFood HypersensitivityGastrointestinal MicrobiomeMalnutritionCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFecesFemaleHumansImmunoglobulin EInfantMaleImmunoglobulin EAllergy and immunologyChildGut microbiotaMalnutrition

Identifiers

PMID40108561
PMCPMC11924646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.