ArticleBMC gastroenterology2025
Nonlinear association between hematocrit levels and short-term all-cause mortality in ICU patients with acute pancreatitis: insights from a retrospective cohort study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Development and validation of dynamic clinical subphenotypes for acute pancreatitis using hematocrit and blood urea nitrogen trajectories in intensive care unit: a multicenter retrospective cohort study.Journal of advanced research · 2026Article
- Prognostic value of the lactate-based modified cally score in postoperative gastric cancer patients admitted to the ICU.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Article
- Calculated serum osmolarity distribution in critically ill patients with acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2026Article
- Development and validation of a 24-h predictive model for hypertriglyceridemic moderately severe acute pancreatitis: a single-center retrospective study.Frontiers in medicine · 2026Article
- Development and validation of a nomogram for predicting 30-day mortality in patients with severe acute pancreatitis and pneumonia.Scientific reports · 2025Article
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Abstract
objectivesThe purpose of this study was to investigate the relationship between hematocrit levels and the mortality of patients with acute pancreatitis (AP), since limited research has examined this association in intensive care unit (ICU).
methodsIn this study, clinical data were retrieved from Medical Information Mart for Intensive Care database for patients diagnosed with AP. Nonlinear relationships between hematocrit and prognosis were examined through Locally Estimated Scatterplot Smoothing (LOESS) regression, restricted cubic splines (RCS), and U-test analyses. The impact of hematocrit on prognosis was further explored using with a binomial generalized linear model with a logit link, while adjusting for potential confounding factors.
resultsThe study encompassed 1,914 patients with AP, revealing a significant difference in hematocrit levels between survivors and non-survivors (33.6 (29.5, 38.1) vs. 32.1 (28.1, 37.4), P < 0.001). Hematocrit emerged as an independent prognostic indicator for mortality in both univariate and multivariate logistic regression analyses (all P < 0.05). Findings from LOESS regression, RCS regression, and the U-test indicated a U-shaped correlation between hematocrit levels and 28-day mortality, with both elevated and decreased hematocrit levels leading to increased mortality risk (P for overall < 0.001). Tertile grouping revealed that lower hematocrit levels (< 30.8%) were associated with heightened 28-day mortality risk (Crude model: Odds ratio (OR) (95%Confidence Interval (CI)) = 1.665 (1.198-2.314); fully adjusted model: adjusted OR = 1.474 (1.005-2.161), all P < 0.05). Survival analyses further supported the adverse prognosis associated with low hematocrit levels.
conclusionsThe findings of this study indicate that in AP patients in the intensive care unit, only low HCT levels were identified as a risk factor for 28-day mortality, despite the presence of a U-shaped correlation between HCT levels and 28-day all-cause mortality.
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