ArticleBMC infectious diseases2025
Treatment outcomes of patients with uncomplicated malaria and associated factors in Northwest Ethiopia: a prospective follow-up study, 2024.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria is the major public health problem in low-income countries like Ethiopia. Despite extensive interventional studies being conducted to attain the 2030 malaria elimination goals, there is limited data on the treatment outcomes of uncomplicated malaria in Ethiopia. Thus, this study aimed to assess the treatment outcomes and associated factors of uncomplicated malaria in Northwest Ethiopia.
methodsThis study was conducted in two health centers, Kolla Diba and Forhe-Sankira, located in Dembia and North Achefer Districts, from April to June 2024. Data was collected from 460 study participants who presented with signs and symptoms and from parasitologically confirmed patients. Malaria was confirmed using microscopy and rapid diagnostic tests (RDT). The parasitologically confirmed patients were appointed on the 3rd, 7th, 14th, and 28th days to determine treatment outcomes for those who were parasitemic on the preceding visit or symptomatic at each visit. The collected longitudinal data was entered and cleaned by Epi-data 4.1 and then analyzed using SPSS 25 software. Descriptive statistics were computed. A binary logistic regression model was fitted to identify factors associated with unsuccessful treatment outcomes at a 95% CI, and a p-value ˂ 0.05 was considered significant.
resultsOf the 460 study participants, 234 (50.9%) were parasitologically confirmed. Treatment outcomes were determined for 224 (95.7%) patients. Ten patients were lost to follow-up. The overall unsuccessful treatment rate was 18.8%. No previous malaria attack (AOR = 18.62, 95% CI: 5.15, 67.25), being infected by Plasmodium vivax (AOR = 8.58; 95% CI: 2.85, 25.83), and coartem two times for 3 days plus primaquine for 14 days (AOR = 4.84; 95% CI: 1.83, 12.79) were the identified factors for unsuccessful treatment outcomes. CONCLUSIONS AND RECOMMENDATIONS: This study revealed that a higher proportion of patients had an unsuccessful treatment outcome. No previous malarial attack, being infected by Plasmodium vivax, and coartem plus primaquine were the identified factors for unsuccessful treatment outcomes. We recommend that healthcare providers prescribe first-line antimalarial therapy and appoint patients for follow-up evaluation according to the national guidelines to identify treatment failure early.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.