ArticleNature2025
VDAC2 loss elicits tumour destruction and inflammation for cancer therapy.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Igniting antitumour immunity with cancer cell pyroptosis.Nature reviews. Cancer · 2026Review
- Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma.Cell reports. Medicine · 2026Article
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential.The Journal of clinical investigation · 2026Review
- Photoactivated iridium(III) complexes drive pyroptosis-necroptosis synergy for multi-network photoimmunotherapy of renal cell carcinoma.Smart molecules : open access · 2026Article
- Research progress on VDAC2 in mitochondrial dysfunction-related diseases.Molecular biology reports · 2026Review
- Copper homeostasis and cuproptosis: molecular mechanisms and therapeutic opportunities.Molecular biomedicine · 2026Review
- Specific bile acids can elicit the type-I interferon response through the cGAS-STING pathway.Cell communication and signaling : CCS · 2026Article
- Molecular mechanisms regulating cGAS/STING activation in health and disease.The Journal of clinical investigation · 2026Review
- Elliptical β-barrel deformation underlies gating in VDAC1.Protein science : a publication of the Protein Society · 2026Article
- Mitochondrial Voltage-Dependent Anion Channel: From a Passive Pore to a Cellular Hub Through Protein Complexation.International journal of molecular sciences · 2026Review
- MSTO1 modulates RAD51 activity to safeguard mitochondrial DNA integrity and control immune responses.Cancer gene therapy · 2026Article
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine-ZBTB5-mTORC1 axis.Nature cell biology · 2026Article
- Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review).Oncology reports · 2026Review
- What does BCL-2 do? From new molecular insights to the clinical implications.Cell death and differentiation · 2026Review
- Perspectives from machine learning and multi-omics to decoding the effects of VDAC2 malignant subsets on tumor evolution.NPJ precision oncology · 2026Article
- The importance of mitochondria and mitochondrial calcium signaling in health and disease: an updated outlook on inflammation.Journal of translational medicine · 2026Review
- VDAC2: an emerging pivotal and multifaceted regulator in tumor biology.Apoptosis : an international journal on programmed cell death · 2026Review
- Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Sujing Yuan *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Renqiang Sun *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2796-629X
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4710-1776
Haoran HuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cliff GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sherri RankinDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anil KcDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Gustavo PalaciosDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0001-2483-3774
Xiaoxi MengDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xiang SunDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Peipei ZhouDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xiaoyang YangExperimental Cellular Therapeutics Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2920-7059
Stephen GottschalkDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3991-7468
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. hongbo.chi@stjude.org.ORCID 0000-0002-9997-2496
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9MIntegrating systems immunology with immunometabolism and cancer immunityR35CA253188 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2021 to 2026
$6.0MRegulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1MTranscriptional and metabolic heterogeneity in T cell differentiationR01AI140761 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$3.9MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MBidirectional signaling in T cell differentiationR01AI150241 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.3MEnabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunologyU01CA281868 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi, Jiyang Yu · 2023 to 2026
$3.2MNutrient sensing and lysosomal signaling in regulatory T cells and immune toleranceR01AI150514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2019 to 2023
$2.2MMetabolic checkpoint in TH17 cell differentiationR01AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$2.2MNCI NIH HHS P30 CA021765NCI NIH HHS R35 CA253188NCI NIH HHS U01 CA281868NIAID NIH HHS R01 AI105887NIAID NIH HHS R01 AI131703NIAID NIH HHS R01 AI140761NIAID NIH HHS R01 AI150241NIAID NIH HHS R01 AI150514NIAID NIH HHS R37 AI105887
Abstract
Tumour cells often evade immune pressure exerted by CD8
Indexed as
ImmunotherapyInflammationNeoplasmsVoltage-Dependent Anion Channel 2Animalsbcl-2 Homologous Antagonist-Killer ProteinBH3 Interacting Domain Death Agonist ProteinCD8-Positive T-LymphocytesCell Line, TumorCRISPR-Cas SystemsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHumansInterferon-gammaMaleMembrane Proteinsbcl-2 Homologous Antagonist-Killer ProteinBH3 Interacting Domain Death Agonist ProteincGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseInterferon-gammaMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSting1 protein, mouseSTING ProteinVdac2 protein, mouseVoltage-Dependent Anion Channel 2
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.