ArticleNature2025
Transient silencing of hypermutation preserves B cell affinity during clonal bursting.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Apoptotic Quality Control of Cellular Competence Limits Cryptic Germinal Center B Cell States.bioRxiv : the preprint server for biology · 2026Article
- Germinal Center Selection and Plasma Cell Differentiation.Immunological reviews · 2026Review
- Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis.Nature cardiovascular research · 2026Article
- Article
- Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq.Nature communications · 2026Article
- Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.Immunology and cell biology · 2026Review
- Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center.bioRxiv : the preprint server for biology · 2026Article
- Highlights of 2025: advances in germinal centers.Immunology and cell biology · 2026Review
- Phased fragility and stability of non-genetic B cell states in the germinal center accelerate the genetic evolution of antibodies.Cell systems · 2026Article
- B cell αv integrin regulates tissue specialization and clonal expansion of lung germinal center and memory B cells after viral infection.Science advances · 2026Article
- Clonal dynamics of germinal center refueling by secondary immunization.bioRxiv : the preprint server for biology · 2026Article
- The B-cell Receptor Blueprint in Lymphoma: Mechanisms and Therapeutic Opportunities.Blood cancer discovery · 2026Review
- Article
- B cell receptor stimulation inhibits class switch recombination through elevated DNA repair.DNA repair · 2026Article
- The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase.Nucleic acids research · 2026Article
- Rethinking p16, p53, and HPV in HNCSCC through lessons from glioblastoma subclonal evolution toward patient-centric N-of-1 single-cell RNA sequencing paradigm.World journal of clinical cases · 2025Article
- Dynamics of local B cell migration during affinity maturation in the human tonsil.bioRxiv : the preprint server for biology · 2025Article
- TyCHE enables time-resolved lineage tracing of heterogeneously-evolving populations.bioRxiv : the preprint server for biology · 2025Article
- B cell αv integrin regulates tissue specialization and clonal expansion of lung germinal center and memory B cells after viral infection.bioRxiv : the preprint server for biology · 2025Article
- Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope.Cell reports · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Juhee PaeLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Niklas Schwan *Department of Systems Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany.
Bertrand Ottino-Loffler *Center for Studies in Physics and Biology, The Rockefeller University, New York, NY, USA.
William S DeWitt *Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Amar Garg *Department of Systems Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany.
Juliana BortolattoLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Ashni A VoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Jin-Jie ShenLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-2567-8470
Alvaro HobbsLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Tiago B R CastroLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-0359-0611
Luka MesinLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Frederick A MatsenDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0607-6025
Michael Meyer-HermannDepartment of Systems Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany.ORCID 0000-0002-4300-2474
Gabriel D VictoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA. victora@rockefeller.edu.ORCID 0000-0001-8807-348X
Funding
Dynamics of Antigen-Driven Selection in Germinal CentersR01AI119006 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2017 to 2026
$5.7MB cell clonal selection in gut-associated germinal centersR01AI157137 · NIAID · ROCKEFELLER UNIVERSITY · PI Daniel S Mucida, Gabriel D Victora · 2020 to 2026
$4.8MDefining the role of T cell help in germinal centers by intercellular enzymatic labelingR01AI173086 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2022 to 2026
$4.0MMolecular control of germinal center selection and affinity maturationR01AI139117 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2018 to 2026
$3.9MBlending deep learning with probabilistic mechanistic models to predict and understand the evolution and function of adaptive immune receptorsR01AI146028 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2019 to 2024
$3.4MEuropean Union’s Horizon 2020 research and innovation programmeNIAID NIH HHS R01 AI119006NIAID NIH HHS R01 AI139117NIAID NIH HHS R01 AI146028NIAID NIH HHS R01 AI157137NIAID NIH HHS R01 AI173086
Abstract
In the course of antibody affinity maturation, germinal centre (GC) B cells mutate their immunoglobulin heavy- and light-chain genes in a process known as somatic hypermutation (SHM)
Indexed as
Antibody AffinityB-LymphocytesClone CellsGene SilencingSomatic Hypermutation, ImmunoglobulinAnimalsCell CycleCell ProliferationCyclin-Dependent Kinase 2FemaleGerminal CenterMaleMiceMice, Inbred C57BLCyclin-Dependent Kinase 2
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.