Evidence map›Paper›PMID 40108450›Full record

ArticleNature2025

The somatic mutation landscape of normal gastric epithelium.

Tim H H Coorens, Grace Collord, Hyungchul Jung, Yichen Wang, Luiza Moore, Yvette Hooks, Krishnaa Mahbubani, Simon Y K Law, Helen H N Yan, Siu Tsan Yuen and 5 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. EradicatingBioactive materials · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Mapping the genetic landscape of hereditary diffuse-type gastric cancer progression.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  15. Genome degradation in plant tissue culture.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tim H H CoorensWellcome Sanger Institute, Hinxton, UK. tcoorens@broadinstitute.org.ORCID 0000-0002-5826-3554
Grace CollordWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-1924-4411
Hyungchul JungWellcome Sanger Institute, Hinxton, UK.
Yichen WangWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-5122-7545
Luiza MooreWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-5315-516X
Yvette HooksWellcome Sanger Institute, Hinxton, UK.
Krishnaa MahbubaniDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1327-2334
Simon Y K LawDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, China.
Helen H N YanDepartment of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, China.ORCID 0000-0001-5693-8231
Siu Tsan YuenDepartment of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, China.
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0633-3696
Peter J CampbellWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-3921-0510
Iñigo MartincorenaWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-1122-4416
Suet Yi LeungDepartment of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, China. suetyi@hku.hk.ORCID 0000-0001-8614-4619
Michael R StrattonWellcome Sanger Institute, Hinxton, UK. mrs@sanger.ac.uk.ORCID 0000-0001-6035-153X

Funding

EMBO long-term fellowshipWellcome Trust
6 · The paper itself

Abstract

The landscapes of somatic mutation in normal cells inform us about the processes of mutation and selection operative throughout life, providing insight into normal ageing and the earliest stages of cancer development

Indexed as

Gastric MucosaMutationAdultAgedAged, 80 and overAgingbeta CateninClone CellsCohort StudiesDNA-Binding ProteinsEpithelial CellsFemaleHumansInflammationMaleMetaplasiaARID1A protein, humanbeta CateninCTNNB1 protein, humanDNA-Binding ProteinsTranscription Factors

Identifiers

PMID40108450
PMCPMC11981919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.