ArticlePediatric research2025
Multi-organ dysfunction across the neonatal encephalopathy spectrum.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Novel neonatal hypoxic-ischemic model demonstrates glial activation and memory deficits without neuronal loss.Pediatric research · 2026Article
- Multiorgan impact of neonatal encephalopathy: higher burden in preterm infants.Pediatric research · 2026Article
- A collaborative "THRIVE Fetus to Five" neonatal brain program review.Pediatric research · 2026Review
- Article
- Multi-organ involvement in preterm neonatal encephalopathy.Early human development · 2025Article
- Short-Term Clinical and Biochemical Outcomes of Infants Born After 34 Weeks of Gestation with Mild-to-Moderate Cord Blood Acidosis-A Retrospective Study.Journal of clinical medicine · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundNeonatal hypoxic-ischemic encephalopathy (HIE), the leading cause of neonatal encephalopathy (NE), primarily affects the central nervous system and is associated with multi-organ dysfunction (MOD) and long-term complications. Research often focuses on moderate to severe NE, with limited data on mild cases.
objectiveTo investigate the incidence and severity of MOD in neonates with mild NE and explore its association with HIE severity.
methodsTerm neonates with NE related to HIE diagnosis between 2009 and 2023 were included. Sarnat staging was used to classify cases into mild and moderate/severe. MOD was assessed on days 1 and 3 post-birth through echocardiography, troponin levels, creatinine levels, urine output, and liver function tests.
resultsAmong 452 neonates with HIE (185 mild, 267 moderate/severe), 57% had liver injury, 55% cardiac injury, and 44% kidney injury in the first day of life. Neonates with mild NE had a MOD rate of 23%, lower than the 37% observed in moderate/severe (p = 0.002). When compared to mild, infants with moderate/severe NE had significantly higher incidences of cardiac (69% vs. 31%; p < 0.001), renal (49% vs. 38%; p = 0.067), and hepatic abnormalities (65% vs. 45%; p = 0.005).
conclusionsThis study highlights the risk of extra-cranial organ injury even in infants with mild NE, stressing the importance of monitoring all regardless of severity. IMPACT: Comprehensive study prospectively evaluating end-organ dysfunction in a cohort of neonates diagnosed with mild, moderate, and severe NE.
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