Evidence map›Paper›PMID 40108412›Full record

ReviewNature reviews. Clinical oncology2025

Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care.

Alireza Mansouri, Ahmad Ozair, Debarati Bhanja, Hannah Wilding, Elad Mashiach, Waqas Haque, Nicholas Mikolajewicz, Leonardo de Macedo Filho, Sean S Mahase, Mitchell Machtay and 17 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Alireza MansouriDepartment of Neurosurgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA. amansouri@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0002-7442-7539
Ahmad OzairDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6570-4541
Debarati BhanjaDepartment of Neurological Surgery, NYU Langone Health, New York University, New York, NY, USA.
Hannah WildingDepartment of Neurosurgery, Penn State College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Elad MashiachDepartment of Neurological Surgery, NYU Langone Health, New York University, New York, NY, USA.
Waqas HaqueDivision of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Nicholas MikolajewiczPeter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.
Leonardo de Macedo FilhoPenn State Cancer Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Sean S MahaseDepartment of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA.
Mitchell MachtayDepartment of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA.
Philippe MetellusDepartment of Neurosurgery, Ramsay Santé, Hôpital Privé Clairval, Marseille, France.
Frédéric DhermainRadiation Therapy Department, Institut Gustave Roussy, Villejuif, France.
Jason SheehanDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.
Douglas KondziolkaDepartment of Neurological Surgery, NYU Langone Health, New York University, New York, NY, USA.
L Dade LunsfordDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ajay NiranjanDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Giuseppe MinnitiDepartment of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza IRCCS Neuromed, Pozzilli, Italy.
Jing LiDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Steven N KalkanisDepartment of Neurosurgery, Henry Ford Health System, Detroit, MI, USA.
Patrick Y WenCenter For Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0774-7700
Rupesh KotechaDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.
Michael W McDermottHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9991-7123
Graeme F WoodworthDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9663-0768
Paul D BrownDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Arjun SahgalDepartment of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7991-8970
Manmeet S AhluwaliaHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. manmeeta@baptisthealth.net.ORCID http://orcid.org/0000-0003-3794-9511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of brain metastases is challenging and should ideally be coordinated through a multidisciplinary approach. Stereotactic radiosurgery (SRS) has been the cornerstone of management for most patients with oligometastatic central nervous system involvement (one to four brain metastases), and several technological and therapeutic advances over the past decade have broadened the indications for SRS to include polymetastatic central nervous system involvement (>4 brain metastases), preoperative application and fractionated SRS, as well as combinatorial approaches with targeted therapy and immune-checkpoint inhibitors. For example, improved imaging and frameless head-immobilization technologies have facilitated fractionated SRS for large brain metastases or postsurgical cavities, or lesions in proximity to organs at risk. However, these opportunities come with new challenges and questions, including the implications of tumour histology as well as the role and sequencing of concurrent systemic treatments. In this Review, we discuss these advances and associated challenges in the context of ongoing clinical trials, with insights from a global group of experts, including recommendations for current clinical practice and future investigations. The updates provided herein are meaningful for all practitioners in clinical oncology.

Indexed as

Brain NeoplasmsRadiosurgeryCombined Modality TherapyHumans

Identifiers

PMID40108412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.