Evidence map›Paper›PMID 40108410›Full record

ArticleCell death and differentiation2025

Cryo-EM structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel.

Amrendra Kumar, Juliana da Fonseca Rezende E Mello, Yangyu Wu, Daniel Morris, Ikram Mezghani, Erin Smith, Stephane Rombauts, Peter Bossier, Juno Krahn, Fred J Sigworth and 1 more

Abstract read
In one paragraph

Article in Cell death and differentiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. ATP synthase subunits e and g are essential for CaCell death and differentiation · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amrendra Kumar *Department of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-3599-7520
Juliana da Fonseca Rezende E Mello *Department of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, USA.
Yangyu Wu *Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Daniel MorrisDepartment of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, USA.
Ikram MezghaniDepartment of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, USA.
Erin SmithDepartment of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, USA.
Stephane RombautsDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Peter BossierFaculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
Juno KrahnNational Institute of Environmental Health Sciences, Durham, NC, USA.
Fred J SigworthDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7178-8494
Nelli MnatsakanyanDepartment of Cell and Biological Systems, Penn State College of Medicine, Hershey, PA, USA. nmnatsakanyan@pennstatehealth.psu.edu.ORCID 0000-0001-5363-7409

Funding

FLUCTUATIONS IN IONIC CURRENT THROUGH MEMBRANE CHANNELSR01NS021501 · NINDS · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 1985 to 2024
$10.9M
Structural and functional characterization of ATP synthase c-subunit leak channel and its role in AD pathogenesisRF1AG072484 · NIA · YALE UNIVERSITY · PI MNATSAKANYAN, NELLI · 2021 to 2021
$2.0M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
Structural and functional characterization of ATP synthase c-subunit leak channel and its role in AD pathogenesisR01AG072484 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MNATSAKANYAN, NELLI · 2024 to 2025
$1.4M
Mitochondrial resilience mechanisms of extremophile brine shrimp ArtemiaR21NS137275 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MNATSAKANYAN, NELLI · 2024 to 2025
$460k
NIA NIH HHS R01 AG072484NIA NIH HHS RF1 AG072484NIH HHS S10 OD023603NINDS NIH HHS R01 NS021501NINDS NIH HHS R21 NS137275U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NS137275U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) RF1AG072484
6 · The paper itself

Abstract

Mammalian mitochondria undergo Ca

Indexed as

ArtemiaMitochondriaMitochondrial Proton-Translocating ATPasesAnimalsCalciumCryoelectron MicroscopyMitochondrial Permeability Transition PoreCalciumMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPases

Identifiers

PMID40108410
PMCPMC12325954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.