Evidence map›Paper›PMID 40108282›Full record

ArticleScientific reports2025

Sleep deprivation impairs neurovascular coupling and cerebral vasomotor reactivity.

Krisztina Szonja Rab-Bábel, Dóra Sulina, Cecilia Daniel, Tibor Rab, Norbert Kozák, László Oláh

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Krisztina Szonja Rab-BábelDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Str. 22., 4032, Debrecen, Hungary. babel.szonja@med.unideb.hu.
Dóra SulinaDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Str. 22., 4032, Debrecen, Hungary.
Cecilia DanielDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Str. 22., 4032, Debrecen, Hungary.
Tibor RabDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Str. 22., 4032, Debrecen, Hungary.
Norbert KozákDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Str. 22., 4032, Debrecen, Hungary.
László OláhDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Str. 22., 4032, Debrecen, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep deficiency increases the risk of cerebrovascular diseases. However, the effects of sleep deprivation (SD) on cerebral blood flow have been poorly studied. We examined the effect of 24-h of SD on the resting posterior cerebral artery (PCA) and middle cerebral artery (MCA) flow velocities (FV), the visually evoked FV response in the PCA (neurovascular coupling), and the hypercapnia-induced FV response in the MCA (cerebral vasoreactivity). Visual evoked potential (VEP) and transcranial Doppler examinations were performed in 25 healthy adults before and after 24-h of SD. Cerebral vasoreactivity was measured by breath-holding test in left and right MCA. The visually evoked FV response was evaluated in left and right PCA. There was a tendency for increased resting mean FV in PCA (p = 0.08) and MCA (p = 0.07) after SD. Both the visually evoked FV response in the PCA and the hypercapnia-induced FV increase in the MCA were significantly lower after than before SD, however, no change in VEP amplitudes was found. Our study suggested that the impaired functional stimulation-evoked FV response after SD was not due to a reduced neuronal activation, but probably to a decreased vasodilatory response. Negative effects of SD on cerebral hemodynamics were also demonstrated by reduced cerebral vasoreactivity.

Indexed as

Cerebrovascular CirculationNeurovascular CouplingSleep DeprivationVasomotor SystemAdultBlood Flow VelocityEvoked Potentials, VisualFemaleHumansHypercapniaMaleMiddle Cerebral ArteryPosterior Cerebral ArteryUltrasonography, Doppler, TranscranialYoung AdultCerebral blood flowNeurovascular couplingSleep deprivationTranscranial dopplerVasoreactivity

Identifiers

PMID40108282
PMCPMC11923101

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.