Evidence map›Paper›PMID 40108242›Full record

Observational studyScientific reports2025

Association between pubertal timing and bone and body composition in young adult men.

Leen Antonio, Lærke Priskorn, Stine A Holmboe, Loa Nordkap, Kirstine A Bang, Anders Juul, Dirk Vanderschueren, Niels Jørgensen

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leen AntonioDepartment of Chronic Diseases, Metabolism and Ageing (CHROMETA), Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Lærke PriskornDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Section 5064, Blegdamsvej 9, 2100, Copenhagen, DK, Denmark.
Stine A HolmboeDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Section 5064, Blegdamsvej 9, 2100, Copenhagen, DK, Denmark.
Loa NordkapDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Section 5064, Blegdamsvej 9, 2100, Copenhagen, DK, Denmark.
Kirstine A BangDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Section 5064, Blegdamsvej 9, 2100, Copenhagen, DK, Denmark.
Anders JuulDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Section 5064, Blegdamsvej 9, 2100, Copenhagen, DK, Denmark.
Dirk VanderschuerenDepartment of Chronic Diseases, Metabolism and Ageing (CHROMETA), Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Niels JørgensenDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Section 5064, Blegdamsvej 9, 2100, Copenhagen, DK, Denmark. Niels.Joergensen@regionh.dk.

Funding

Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1800923NKØbmand I Odense Johan og Hanne Weimann FØdt Seedorffs Legat F-24230-01Region Hovedstaden (Capital Region of Denmark) A6176
6 · The paper itself

Abstract

Bone and muscle development are important processes in pubertal maturation. The aim of this study was to investigate associations between pubertal timing and bone density and body composition in young adult men. In this observational study, bone and body composition was cross-sectionally assessed by dual-energy X-ray absorptiometry in 2056 healthy young men with median age 19, who retrospectively self-reported if they experienced pubertal changes at an earlier, similar or later age than their peers. Associations between voice break timing and bone and body composition were analyzed by linear regression. Men reporting earlier voice break than their peers (n = 417, 20%) had higher lumbar bone mineral density (BMD) and higher total body BMD. Apart from higher BMI, there were no differences in body composition. Men who reported later voice break (n = 353, 17%) had lower lumbar bone mineral content, bone area and volume, but similar BMD. They had lower BMI, lean mass and fat mass, resulting in a lower fat-to-muscle ratio. In conclusion, even after adult height has been reached, physiological variations in pubertal timing were associated with differences in bone and body composition in young adult men.

Indexed as

Body CompositionBone DensityPubertyAbsorptiometry, PhotonAdolescentAdultBody Mass IndexCross-Sectional StudiesHumansMaleRetrospective StudiesYoung AdultBody compositionBone densityPubertyVoice break

Identifiers

PMID40108242
PMCPMC11923200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.