ArticleScientific reports2025
Comparative toxicotranscriptomics of longterm cypermethrin exposure to aquacultured fish Labeo catla (Catla).
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Cypermethrin (CYP), a persistent synthetic pyrethroid, poses a significant threat to aquatic life. The present work aims to identify the effect of CYP on the brain and liver transcriptome profile of fish Labeo catla. CYP (0.7 µg/L) was long-term exposed to L catla, and differentially expressed genes (DEGs) were investigated using RNA-sequencing (Illumina HiSeq2500). A total of 2665 and 18,020 unigenes and 333 and 454 DEGs were identified in the brain and liver transcriptome, respectively. DEGs associated with MAPK signaling and apoptosis pathways were co-expressed in both brain and liver transcriptome, according to pathway enrichment analysis. Concurrently, steroid and terpenoid backbone biosynthesis were overexpressed in liver, suggesting induction of apoptosis and steroid production, respectively. Among the identified DEGs, fosab, nr4a1, dhcr24 and tm7sf2 were significantly enriched and molecular docking studies further supported our findings. Long-term CYP exposure also altered the levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and malondialdehyde (MDA) content in L. catla. The present study provides significant insights into the consequences of CYP-induced toxicity in fish and identified functional genes that could be screened for estimating the toxic load of CYP in future ecotoxicological risk assessment studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.