ArticleNature communications2025
Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Acquisition-Recruited and MOR-Expressing Striatal dMSNs Differentially Regulate Extinction and Cue-Induced Relapse of Alcohol Seeking.Addiction biology · 2026Article
- Targeting GPCR Signaling in Parkinson's Disease: From Molecular Pathology to Exercise-Based Therapeutics.Molecular neurobiology · 2026Review
- Extended Amygdala CRF Projections to Striatal Striosomes Potentiate Dopamine Suppression During Fentanyl Withdrawal.bioRxiv : the preprint server for biology · 2026Article
- Nicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopaminergic Signaling Independent of Neuron Survival in a Double-Hit Parkinson's Model.Research square · 2026Article
- Dual-engram architecture within a single striatal cell type distinctly controls alcohol relapse and extinction.Neuron · 2026Article
- Npas4 regulates synaptic development in the patch/striosome compartment and early affective vocalization in neonatal mice.Molecular brain · 2026Article
- Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons.Brain structure & function · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Extinction Training Suppresses Alcohol Relapse by Inhibiting Acquisition-Recruited Striatal Ensembles and Engaging Striosomal Neurons.bioRxiv : the preprint server for biology · 2026Article
- Dual Engram Architecture within a Single Striatal Cell Type Distinctly Controls Alcohol Relapse and Extinction.bioRxiv : the preprint server for biology · 2026Article
- Developmental dopamine loss rewires striatal circuits to promote locomotion.Molecular neurodegeneration · 2026Article
- Whole-brain input organization ofFrontiers in neural circuits · 2026Article
- Patchy striatonigral neurons modulate locomotor vigor in response to environmental valence.eLife · 2025Article
- Developmental Dopamine Loss Rewires Striatal Circuits to Promote Locomotion.Research square · 2025Article
- Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence.bioRxiv : the preprint server for biology · 2025Article
- Parkinson's Disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input.bioRxiv : the preprint server for biology · 2025Article
- Striosome Circuitry Stimulation Inhibits Striatal Dopamine Release and Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Muscarinic receptor activation preferentially inhibits rebound in vulnerable dopaminergic neurons.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
10 authors.
Jie DongTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Lupeng WangTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-3706-4564
Breanna T SullivanTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-8597-2276
Lixin SunTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Victor M Martinez SmithTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0009-0005-6826-4226
Lisa ChangTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Jinhui DingComputational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Weidong LeClinical Research Center on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, 116011, China.ORCID http://orcid.org/0000-0001-7459-2705
Charles R GerfenSection on Neuroanatomy, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-9008-4882
Huaibin CaiTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA. caih@mail.nih.gov.ORCID http://orcid.org/0000-0002-8596-6108
Funding
Functional Organization Of The Cerebral Cortex and Basal GangliaZIAMH002497 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI GERFEN, CHARLES R · 2009 to 2025
$18.3MThe Function and Pathogenic Mechanisms of LRRK2/Dardarin in Parkinson's DiseaseZIAAG000944 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2025
$10.2MFUNCTIONAL ORGANIZATION OF THE BASAL GANGLIAZ01MH002497 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI GERFEN, CHARLES R · 1990 to 2008
$1.7MThe Function and Pathogenic Mechanisms of LRRK2/Dardarin in Parkinson's DiseaseZ01AG000944 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2008 to 2008
$499kIntramural NIH HHS Z01 AG000944Intramural NIH HHS Z01 MH002497Intramural NIH HHS ZIA AG000944Intramural NIH HHS ZIA MH002497National Natural Science Foundation of China (National Science Foundation of China) 32220103006U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) ZIA AG000944, AG000928
Abstract
Striatonigral neurons, traditionally known for promoting locomotion, comprise diverse subtypes with distinct transcriptomic profiles. However, their specific contributions to locomotor regulation remain incompletely understood. Using the genetic markers Kremen1 and Calb1, we demonstrate in mouse models that Kremen1
Indexed as
Corpus StriatumDopaminergic NeuronsLocomotionNeuronsSubstantia NigraAnimalsDopamineFemaleMaleMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicOptogeneticsReceptors, GABA-BDopamineMembrane ProteinsReceptors, GABA-B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.