Evidence map›Paper›PMID 40108118›Full record

ArticleInternational journal of oral science2025

Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren's syndrome.

Xiangdi Mao, Haibing Li, Sainan Min, Jiazeng Su, Pan Wei, Yan Zhang, Qihua He, Liling Wu, Guangyan Yu, Xin Cong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oral science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Molecular Insights into Oral Manifestations in Sjögren's Disease.International journal of molecular sciences · 2026
    Review
  3. [Research progress in diagnosis and treatment of non-tumorous salivary gland diseases].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangdi MaoDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing, China.ORCID 0000-0002-3728-3687
Haibing LiDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing, China.
Sainan MinDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Jiazeng SuDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Pan WeiDepartment of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Yan ZhangDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing, China.
Qihua HeState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
Liling WuDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing, China.
Guangyan YuDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Xin CongDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Beijing, China. congxin@bjmu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31972908, 81991500, and 81991502National Natural Science Foundation of China (National Science Foundation of China) 32030010Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 7202082
6 · The paper itself

Abstract

Tricellulin, a key tricellular tight junction (TJ) protein, is essential for maintaining the barrier integrity of acinar epithelia against macromolecular passage in salivary glands. This study aims to explore the role and regulatory mechanism of tricellulin in the development of salivary gland hypofunction in Sjögren's syndrome (SS). Employing a multifaceted approach involving patient biopsies, non-obese diabetic (NOD) mice as a SS model, salivary gland acinar cell-specific tricellulin conditional knockout (Tric

Indexed as

MARVEL Domain Containing 2 ProteinSjogren's SyndromeTight JunctionsXerostomiaAnimalsDisease Models, AnimalFemaleHumansInterferon-gammaMiceMice, Inbred NODMice, KnockoutMicroRNAsSalivary GlandsInterferon-gammaMARVELD2 protein, humanMARVEL Domain Containing 2 ProteinMicroRNAs

Identifiers

PMID40108118
PMCPMC11923234

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.