Evidence map›Paper›PMID 40107623›Full record

ArticleInternational journal of radiation oncology, biology, physics2025

Neurocognitive and Resting-State Functional Magnetic Resonance Imaging Changes in Patients With Diffuse Gliomas After Chemoradiation Therapy.

Zhihua Liu, Timothy J Mitchell, Chongliang Luo, Ki Yun Park, Joshua S Shimony, Robert Fucetola, Eric C Leuthardt, Stephanie M Perkins, Abraham Z Snyder, Tong Zhu and 1 more

Abstract read
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhihua LiuDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri.
Timothy J MitchellDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri.
Chongliang LuoDivision of Public Health Sciences, Washington University School of Medicine, St Louis, Missouri.
Ki Yun ParkMedical Scientist Training Program, Washington University School of Medicine, St. Louis, Missouri.
Joshua S ShimonyDepartment of Radiology, Division of Medical Oncology, Washington University School of Medicine, St Louis, Missouri.
Robert FucetolaDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri.
Eric C LeuthardtDepartment of Neurological Surgery and Division of Neurotechnology, Washington University School of Medicine, St Louis, Missouri; Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Stephanie M PerkinsDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri; Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Abraham Z SnyderDepartment of Radiology, Division of Medical Oncology, Washington University School of Medicine, St Louis, Missouri.
Tong ZhuDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri.
Jiayi HuangDepartment of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri; Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri. Electronic address: Jiayi.huang@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Augmented Neurosurgical Navigation Software Using Resting State MRIR01CA203861 · NCI · WASHINGTON UNIVERSITY · PI Eric CLAUDE Leuthardt, JOSHUA S SHIMONY · 2017 to 2026
$5.8M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA203861
6 · The paper itself

Abstract

purposeThis prospective observational study employed resting-state functional magnetic resonance imaging (rs-fMRI) to investigate network-level disturbances associated with neurocognitive function (NCF) changes in patients with gliomas following partial-brain radiation therapy (RT). METHODS AND MATERIALS: Adult postoperative patients with either isocitrate dehydrogenase (IDH)-wild-type or IDH-mutant gliomas underwent computerized NCF testing and rs-fMRI at baseline and 6 months post-RT. rs-fMRI data were assessed using seed-based functional connectivity (FC). NCF changes were quantified by the percent change in age-normalized composite scores from baseline (ΔNCF

resultsBetween September 2020 and December 2023, 43 patients were enrolled, with 32 completing both baseline and follow-up evaluations. The mean ΔNCF

conclusionsPost-RT rs-fMRI changes significantly reflected NCF decline, highlighting rs-fMRI as a promising imaging biomarker for neurocognitive decline after RT.

Indexed as

Brain NeoplasmsChemoradiotherapyCognitionGliomaMagnetic Resonance ImagingAdultAgedBrainFemaleHumansIsocitrate DehydrogenaseMaleMiddle AgedMutationProspective StudiesIsocitrate Dehydrogenase

Identifiers

PMID40107623
PMCPMC12404197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.