ArticleResuscitation2025
The apnea interval: Ventilation interruption during tracheal intubation and its association with cardiac arrest resuscitation care and outcome.
Article in Resuscitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- First responder airway and compression rate cluster randomized controlled trial: rational and design.Resuscitation plus · 2026Article
- Airway management by ambulance nurses during out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundGuidelines for out-of-hospital cardiac arrest (OHCA) resuscitation recommend advanced airway management without interrupting chest compressions. However, the extent and impact of interrupting ventilation is unknown. We described the apnea interval that occurs during tracheal intubation and its association with clinical outcomes.
methodsWe conducted a cohort investigation of adult ventricular fibrillation (VF) OHCA patients who underwent attempted tracheal intubation prior to return of spontaneous circulation (ROSC) in a metropolitan EMS system (2017-2020). Apnea interval was defined as elapsed time between last breath delivered before and first breath delivered following tracheal intubation attempt. We used multivariable logistic regression to determine the relationship between apnea interval (≤60 s vs > 60 s) and outcomes: ROSC, survival to hospital discharge, and favorable neurologic survival (CPC 1-2).
resultsAmong 254 patients, median age was 65 years, 18% were female, and 98% had tracheal intubation success. Overall, 151 (59%) achieved ROSC, 71 (28%) survived to discharge, and 67 (26%) with favorable survival. The median apnea interval during attempted tracheal intubation was 84 s (64-113 s). Median chest compression fraction was 85% overall and 87% during the apnea interval. In unadjusted and adjusted analyses, a shorter apnea interval was associated with better outcomes: ROSC (72% vs 56%), survival (39% vs 25%), and favorable survival (39% vs 23%) (p < 0.05 for each comparison).
conclusionsIn this VF-OHCA cohort, shorter apnea intervals (≤60 s) were associated with greater likelihood of favorable outcomes. Given its variability and relationship to outcomes, the apnea interval may be a modifiable measure to improve OHCA survival.
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