Evidence map›Paper›PMID 40107243›Full record

ArticleCell reports. Medicine2025

High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation.

Hamed Moheimani, Xuejing Sun, Mehves Ozel, Jennifer L Darby, Erika P Ong, Tunde Oyebamiji, Upendra K Kar, Mark H Yazer, Matthew D Neal, Francis X Guyette and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hamed MoheimaniDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Xuejing SunDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Mehves OzelDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Jennifer L DarbyDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Erika P OngDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Tunde OyebamijiDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Upendra K KarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Mark H YazerDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Matthew D NealDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Francis X GuyetteDepartment of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Stephen R WisniewskiDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Bryan A CottonDepartment of Surgery, University of Texas Health Science Center, Houston, TX, USA.
Jeremy W CannonDepartment of Surgery, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
Martin A SchreiberDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MA, USA.
Ernest E MooreDepartment of Surgery, Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado Health Sciences Center, Denver, CO, USA.
Nicholas NamiasDepartment of Surgery, University of Miami/Jackson Memorial Hospital, Miami, FL, USA.
Joseph P MineiDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Christopher D BarrettDivision of Acute Care Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA; Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
Jishnu DasCenter for Systems Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Jason L SperryDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: sperryjl@upmc.edu.
Timothy R BilliarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: billiartr@upmc.edu.
SWAT study group

Funding

Using Patient-Reported Outcomes, Inflammatory Profiles, and Cardiovascular Phenogroups to Expand the Definition of Heart Failure with Preserved Ejection FractionP20GM152326 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Marian Urban · 2024 to 2026
$10.3M
TRAINING IN TRAUMA AND SEPSIS RESEARCHT32GM008516 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 1994 to 2026
$9.4M
Endothelial Dysfunction and Restoration in Trauma Induced CoagulopathyR01HL166944 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mitchell Cohen, Kalev Freeman · 2023 to 2026
$9.2M
Mechanisms of Immune Dysfunction after Trauma and Surgical SepsisR35GM127027 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 2018 to 2026
$5.7M
Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9M
Mechanisms of Complement Activation in Traumatic InjuryK08HL171936 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Christopher David Barrett · 2024 to 2026
$500k
NHLBI NIH HHS K08 HL171936NHLBI NIH HHS R01 HL166944NIGMS NIH HHS P20 GM152326NIGMS NIH HHS R35 GM119526NIGMS NIH HHS R35 GM127027NIGMS NIH HHS T32 GM008516
6 · The paper itself

Abstract

Early blood product resuscitation is often essential for optimal trauma care. However, the effects of different products on the underlying trauma-induced coagulopathy and immune dysfunction are not well described. Here, we use high-dimensional analysis and causal modeling in a longitudinal study to explore the circulating proteomic response to plasma as a distinct component versus low-titer O whole blood (LTOWB), which contains plasma. We highlight the differential impacts of plasma and LTOWB on immune mediator levels and the distinct capacity of plasma to modulate coagulation by elevating fibrinogen and factor XIII and reducing platelet factor 4. A higher proportion of plasma in prehospital resuscitation is associated with improved admission time coagulation parameters in patients with severe shock and elevated brain injury markers and reduced post-admission transfusion volumes in those suffering from traumatic brain injury (TBI) and blunt injury. While LTOWB offers broad hemostatic benefits, our findings demonstrate specific advantages of plasma and support individualized transfusion strategies.

Indexed as

Brain Injuries, TraumaticPlasmaProteomeProteomicsResuscitationWounds and InjuriesAdultBlood CoagulationBlood TransfusionFemaleFibrinogenHumansLongitudinal StudiesMaleMiddle AgedFibrinogenProteomeblood coagulationblood transfusionfibrinogeninnate immunityplasmaplatelet activationplatelet factor 4precision medicineproteomicstraumatic brain injury

Identifiers

PMID40107243
PMCPMC11970397

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.