Evidence map›Paper›PMID 40107110›Full record

ArticleBiochemical and biophysical research communications2025

Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer.

Samaneh Ghazanfarpour, Alireza Sheikhsofla, Monireh Pourrahimi, Satish Sharma, Andrew Skomra, Anna Sharikova, Stanley A Schwartz, Supriya D Mahajan, Alexander Khmaladze, Ravikumar Aalinkeel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samaneh GhazanfarpourDepartment of Physics, University at Albany SUNY, 1400 Washington Avenue, Albany, NY, 12222, USA.
Alireza SheikhsoflaDepartment of Physics, University at Albany SUNY, 1400 Washington Avenue, Albany, NY, 12222, USA.
Monireh PourrahimiDepartment of Physics, University at Albany SUNY, 1400 Washington Avenue, Albany, NY, 12222, USA.
Satish SharmaDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical Translational Research Center, Buffalo, NY, 14203, USA; Department of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Andrew SkomraDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical Translational Research Center, Buffalo, NY, 14203, USA.
Anna SharikovaDepartment of Physics, University at Albany SUNY, 1400 Washington Avenue, Albany, NY, 12222, USA.
Stanley A SchwartzDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical Translational Research Center, Buffalo, NY, 14203, USA.
Supriya D MahajanDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical Translational Research Center, Buffalo, NY, 14203, USA.
Alexander KhmaladzeDepartment of Physics, University at Albany SUNY, 1400 Washington Avenue, Albany, NY, 12222, USA.
Ravikumar AalinkeelDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical Translational Research Center, Buffalo, NY, 14203, USA; Department of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Funding

A novel phase and spectroscopic imaging technique to evaluate mitochondrial dynamicsR01DA047410 · NIDA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI KHMALADZE, ALEXANDER, MAHAJAN, SUPRIYA DINKAR · 2019 to 2021
$1.1M
BLRD VA I01 BX005318NIDA NIH HHS R01 DA047410
6 · The paper itself

Abstract

Glycoproteins, such as Galectin-3 (Gal-3) and Prostate Specific Membrane Antigen (PSMA), are functional proteins involved in numerous biological activities that include cell apoptosis, angiogenesis, and inflammation. Downregulation of both in the highly metastatic human Prostate Cancer (CaP) cell line PC-3 reduces tumor growth. We used Raman Spectroscopy (RS) to examine the effect of a potent Gal-3 inhibitor (GB1107) in CaP cell lines of varying metastatic potential, namely PC-3, DU-145 and LNCaP. All three cancer lines had distinct Raman signatures. Raman spectra from PC-3, DU-145 and LNCaP cells treated with GB1107, compared to the untreated cells as controls, showed significant differences corresponding to changes in phosphatidylinositol (peak at 596 cm

Indexed as

Antineoplastic AgentsGalectin 3Prostatic NeoplasmsSpectrum Analysis, RamanBlood ProteinsCell Line, TumorGalectinsHumansMaleAntineoplastic AgentsBlood ProteinsGalectin 3GalectinsLGALS3 protein, humanGalectinsGlycoproteinsMetastasisProstate cancer (CaP)Prostate specific membrane antigen (PSMA)Raman spectroscopy (RS)Singular value decomposition (SVD) analysisTumor microenvironment

Identifiers

PMID40107110
PMCPMC13548200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.