Evidence map›Paper›PMID 40106801›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

Single-Cell RNA Sequencing Identifies a Unique Macrophage Population in a Mouse Model of Ozone-induced Asthma Exacerbation.

Jess L Ray, Joshua Walum, Daria Jelic, Ryelie Barnes, Ian D Bentley, Rodney D Britt, Joshua A Englert, Megan N Ballinger

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Single-cell transcriptomics reveal alveolar macrophage-specific responses in single-hit ozone exposure model in mice.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jess L RayDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, and.ORCID 0000-0002-5387-9026
Joshua WalumCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.ORCID 0000-0002-0414-4621
Daria JelicDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, and.ORCID 0009-0005-7225-0273
Ryelie BarnesDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, and.ORCID 0009-0003-1766-8816
Ian D BentleyDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, and.ORCID 0000-0001-7237-3082
Rodney D BrittDepartment of Pediatrics, The Ohio State University, Columbus, Ohio; and.ORCID 0000-0002-0027-9545
Joshua A EnglertDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, and.ORCID 0000-0002-1257-2239
Megan N BallingerDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute, and.ORCID 0000-0002-2202-3049

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
The pivotal role of macrophages in regulating pulmonary fibrosisR01HL141217 · NHLBI · OHIO STATE UNIVERSITY · PI BALLINGER, MEGAN N · 2019 to 2023
$2.5M
Cellular Senescence in Neonatal AirwaysR01HL158532 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 2022 to 2025
$2.5M
Airway Structural Cells and Corticosteroid Resistance in AsthmaR01HL155095 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRITT, RODNEY · 2021 to 2025
$2.5M
NCI NIH HHS P30 CA016058NCI NIH HHS U24-HL148865NHLBI NIH HHSNHLBI NIH HHS R01 HL141217NHLBI NIH HHS R01 HL155095NHLBI NIH HHS R01 HL158532Ohio State University College of Medicine Office of Research Dean's Discovery Program
6 · The paper itself

Abstract

Ozone (O

Indexed as

AsthmaMacrophages, AlveolarOzoneSequence Analysis, RNASingle-Cell AnalysisAnimalsDisease Models, AnimalFemaleLungMiceMice, Inbred C57BLOzoneasthmamacrophagemonocyteozonesingle-cell RNA sequencing

Identifiers

PMID40106801
PMCPMC12499925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.