Evidence map›Paper›PMID 40106756›Full record

ArticleNeurology2025

Long-Term Clinical Landscapes of Spinal Hypertrophic Pachymeningitis With Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.

Akihiro Nakajima, Mariko Hokari, Fumihiro Yanagimura, Etsuji Saji, Hiroshi Shimizu, Yasuko Toyoshima, Kaori Yanagawa, Musashi Arakawa, Akiko Yokoseki, Takahiro Wakasugi and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Akihiro NakajimaDepartment of Neurology, Brain Research Institute, Niigata University, Japan.ORCID 0009-0001-0278-4131
Mariko HokariDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Fumihiro YanagimuraDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Etsuji SajiDepartment of Neurology, Brain Research Institute, Niigata University, Japan.ORCID 0000-0003-2743-3175
Hiroshi ShimizuDepartment of Pathology, Brain Research Institute, Niigata University, Japan.
Yasuko ToyoshimaDepartment of Pathology, Brain Research Institute, Niigata University, Japan.
Kaori YanagawaDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Musashi ArakawaDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Akiko YokosekiDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Takahiro WakasugiDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Kouichirou OkamotoDepartment of Neurosurgery, Brain Research Institute, Niigata University, Japan.
Kei WatanabeDepartment of Orthopaedic Surgery, Niigata University Medical and Dental Hospital, Japan.
Keitaro MinatoDepartment of Orthopaedic Surgery, Niigata University Medical and Dental Hospital, Japan.
Yutaka OtsuDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Yukiko NozawaDivision of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Daisuke KobayashiDivision of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Kazuhiro SanpeiDepartment of Neurology, Sado General Hospital, Japan.
Hirotoshi KikuchiDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Shunsei HirohataDepartment of Rheumatology, Nobuhara Hospital, Tatsuno, Japan.
Kazuaki AwamoriDepartment of Neurology, Kaetsu Hospital, Niigata, Japan.
Aya NawataDepartment of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
Mitsunori YamadaDepartment of Brain Disease Research, Shinshu University School of Medicine, Matsumoto, Japan.
Hitoshi TakahashiDepartment of Pathology, Brain Research Institute, Niigata University, Japan.
Masatoyo NishizawaDepartment of Neurology, Brain Research Institute, Niigata University, Japan.
Hironaka IgarashiCenter for Integrated Human Brain Science, Brain Research Institute, Niigata University, Japan.ORCID 0000-0003-1663-5564
Noboru SatoDivision of Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Japan; and.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Japan.ORCID 0000-0003-4244-0277
Osamu OnoderaDepartment of Neurology, Brain Research Institute, Niigata University, Japan.ORCID 0000-0003-3354-5472
Izumi KawachiDepartment of Neurology, Brain Research Institute, Niigata University, Japan.ORCID 0000-0002-7140-8500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSpinal hypertrophic pachymeningitis (HP) is an extremely rare disorder characterized by the thickening of the spinal dura mater, which harbors distinct repertoires of immune cells due to the unique partitioning of the arachnoid blood-CSF barrier. The objectives were to identify the pathogenesis and therapeutic strategies for spinal HP.

methodsThis retrospective cohort study analyzed the clinical and pathologic profiles of patients with idiopathic/immune-mediated HP including spinal HP.

resultsAmong 61 patients with idiopathic/immune-mediated HP, all 6 Japanese patients with spinal HP, with a median observation period of 88.8 months, were myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA)-seropositive. The MPO-ANCA DISCUSSION: Our findings highlight the significant pathogenic role of ANCA in spinal HP. MPO-ANCA

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisMeningitisAdultAgedAged, 80 and overAntibodies, Antineutrophil CytoplasmicCohort StudiesDura MaterFemaleHumansHypertrophyMaleMiddle AgedPeroxidaseRetrospective StudiesAntibodies, Antineutrophil CytoplasmicPeroxidase

Identifiers

PMID40106756
PMCPMC11919275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.