Evidence map›Paper›PMID 40106653›Full record

Observational studyEuropean journal of preventive cardiology2025

Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study.

Soroush Masrouri, Peyman Tabnak, Parag A Chevli, Saeid Mirzai, Leandro Slipczuk, Sujethra Vasu, Joao A C Lima, Michael D Shapiro

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soroush MasrouriPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Yamen Street, Velenjak, Tehran 1985717413, Iran.
Peyman TabnakImmunology Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz 5166614766, Iran.
Parag A ChevliSection on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, USA.
Saeid MirzaiSection on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, USA.
Leandro SlipczukDivision of Cardiology, Montefiore Healthcare Network/Albert Einstein College of Medicine, 111 East 210th Street, Bronx, NY 10467, USA.ORCID 0000-0003-3091-3735
Sujethra VasuSection on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, USA.
Joao A C LimaDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA.ORCID 0000-0001-8756-6995
Michael D ShapiroSection on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, USA.ORCID 0000-0002-9071-3287

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS UL1-TR-000040NHLBI NIH HHS UL1-TR-001079NHLBI NIH HHS UL1-TR-001420
6 · The paper itself

Abstract

aimsThis study examined the associations between decade-long cumulative blood pressure (BP) exposure and global/regional myocardial structure and function independent of current BP levels. METHODS AND

resultsWe analysed 3015 adults (aged 69.0 ± 9.2 years) from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent cardiac magnetic resonance (CMR) imaging at Year 10 (Exam 5, 2010-12). Measures included left ventricular (LV) parameters, global/regional myocardial function via tagged CMR, interstitial myocardial fibrosis via T1-mapping measures (native T1 and extracellular volume fraction), and myocardial scar via late gadolinium enhancement. We used cumulative exposure to BP through baseline and up to Exam 5 (millimetres of mercury × year) to represent long-term exposure to BP levels. Linear regression, logistic regression, and generalized additive models were used to quantify the association of cumulative BP parameters with measures of cardiac structure and function. Higher cumulative systolic BP (SBP), independent of current SBP, correlated with increased LV mass index [1.93 g/m2 per standard deviation (SD)], worse global/regional circumferential strain (0.24-0.38% lower absolute values per SD), and greater myocardial scar risk [odds ratio (OR): 1.36, 95% confidence interval (CI): 1.02-1.82 per SD]. Cumulative diastolic BP (DBP) was associated with circumferential strain, showing nearly J-shaped relationships after adjusting for current DBP (all P < 0.05). In non-hypertensive individuals with BP consistently below the hypertension threshold, cumulative SBP remained significantly associated with LV mass index and strain but not myocardial scar (OR: 1.53, 95% CI: 0.82-2.87, P = 0.19).

conclusionHigher cumulative BP was associated with worse global and regional cardiac structure/function and myocardial scar, independent of a single BP at the time of imaging, and was still observed to some extent in non-hypertensive individuals who consistently maintained BP levels below the hypertension threshold.

Indexed as

Blood PressureHypertensionMyocardiumVentricular Function, LeftVentricular RemodelingAgedAged, 80 and overFemaleFibrosisHumansMagnetic Resonance Imaging, CineMaleMiddle AgedRisk AssessmentRisk FactorsTime FactorsBlood pressureCardiac magnetic resonance imagingCardiac structure and functionMulti-Ethnic Study of Atherosclerosis

Identifiers

PMID40106653
PMCPMC12510735

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.