Evidence map›Paper›PMID 40106572›Full record

ArticleScience advances2025

The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly.

Liuyi Hu, Alan Wainman, Antonina Andreeva, Muladili Apizi, Ines Alvarez-Rodrigo, Siu-Shing Wong, Saroj Saurya, Devon Sheppard, Matthew Cottee, Steven Johnson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liuyi HuState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0009-0000-2097-6447
Alan WainmanSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0002-6292-4183
Antonina AndreevaMedical Research Council-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-0450-0091
Muladili ApiziState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0009-0004-1843-9027
Ines Alvarez-RodrigoSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0003-2181-5535
Siu-Shing WongSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0002-5327-8466
Saroj SauryaSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0003-4057-0123
Devon SheppardSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0002-9371-4429
Matthew CotteeSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0002-3619-3057
Steven JohnsonSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0002-7877-3543
Susan M LeaSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0001-9287-8053
Jordan W RaffSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.ORCID 0000-0002-4689-1297
Mark van BreugelMedical Research Council-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-1050-0300
Zhe FengState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0000-0002-0106-6023

Funding

Wellcome Trust
6 · The paper itself

Abstract

Centrosomes form when centrioles assemble pericentriolar material (PCM) around themselves. Spd-2/CEP192 proteins, defined by a conserved "Spd-2 domain" (SP2D) comprising two closely spaced AspM-Spd-2-Hydin (ASH) domains, play a critical role in centrosome assembly. Here, we show that the SP2D does not target

Indexed as

Cell Cycle ProteinsCentrosomeDrosophila ProteinsProtein FoldingAmino Acid SequenceAnimalsCentriolesConserved SequenceCrystallography, X-RayHumansMaleModels, MolecularMutationPhosphorylationProtein DomainsProtein MultimerizationCell Cycle ProteinsDrosophila ProteinsProtein Serine-Threonine Kinases

Identifiers

PMID40106572
PMCPMC11922060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.