ArticleScience advances2025
Deep tissue sensing of chiral molecules using polarization-enhanced photoacoustics.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Stereochemical Terminology in Chiral Drugs: Still Between Confusion and Misinterpretation.ACS medicinal chemistry letters · 2026Article
- Photoacoustic Noninvasive Blood Glucose Monitoring: A Review of Systems and Strategies for Robust Glucose Concentration Estimation, with Perspectives on Miniaturization and Wearability.Sensors (Basel, Switzerland) · 2026Review
- Comprehensive study on the characterization of lysed blood samples using dual-wavelength photoacoustics.Journal of biomedical optics · 2026Article
- Rapid enantioselective fluorescence recognition and chiral separation of free amino acids.Nature communications · 2026Article
- Sinogram to image: direct reconstruction of photoacoustic tomography image using a hybrid deep learning approach.Biomedical optics express · 2025Article
- Performance characterization of light-emitting diode array-based photoacoustic computed tomography (LED-PACT).Biomedical optics express · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Chiral molecule sensing is typically performed using techniques like chromatography, electrophoresis, enzymatic assays, mass spectrometry, and chiroptical methods. While polarimetry allows for in vivo sensing up to 1 mm depth using ultraviolet-visible light, it is limited by dominant light scattering beyond this depth. We propose that photoacoustic sensing in the near-infrared II (NIR-II) window can enable deep tissue sensing as acoustic waves scatter less than light. To achieve this, we developed a photoacoustic polarization-enhanced optical rotation sensing (PAPEORS) system, capable of estimating optical rotation from photoacoustic signals and correlating it with chiral molecular concentration for depths up to 3.5 mm. Experiments were conducted using aqueous glucose solutions, naproxen, serum-based glucose samples, and ex vivo chicken tissue. PAPEORS achieved a detection limit of 80 mg/dl while using circularly polarized light with serum samples, demonstrating the potential for deep-tissue chiral molecular sensing. PAPEORS holds promise for in vivo sensing and easy miniaturization using single wavelength.
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Registered trials
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