Evidence map›Paper›PMID 40106561›Full record

ArticleScience advances2025

Short-lived reactive components substantially contribute to particulate matter oxidative potential.

Steven J Campbell, Battist Utinger, Alexandre Barth, Zaira Leni, Zhi-Hui Zhang, Julian Resch, Kangwei Li, Sarah S Steimer, Catherine Banach, Benjamin Gfeller and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Unraveling the Different Drivers of PMEnvironmental science & technology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Steven J CampbellMRC Centre for Environment and Health, Environmental Research Group, Imperial College London, 86 Wood Lane, London W12 0BZ, UK.ORCID 0000-0002-1334-3681
Battist UtingerDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.
Alexandre BarthDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0009-0000-5404-2239
Zaira LeniInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-6794-1727
Zhi-Hui ZhangDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.
Julian ReschDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0000-0002-9905-3959
Kangwei LiDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0000-0001-7084-3861
Sarah S SteimerDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0000-0002-1955-9467
Catherine BanachDepartment of Atmospheric and Oceanic Sciences, University of California at Los Angeles, 405 Hilgard Ave, Portola Plaza, Los Angeles, CA 90095-1565, USA.ORCID 0000-0001-6038-1624
Benjamin GfellerDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0009-0008-1573-3297
Francis P H WraggYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0002-1711-0930
Joe WestwoodYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Kate WolferDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0000-0002-5299-0638
Nicolas BukowieckiDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0000-0002-2925-8553
Mika IhalainenDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.ORCID 0000-0003-1834-7558
Pasi Yli-PiriläDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Markus SomeroDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Miika KortelainenDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.ORCID 0000-0002-1051-4617
Juho LouhisalmiDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.ORCID 0009-0007-4134-8467
Martin SklorzInstitute of Chemistry, University of Rostock, Albert-Einstein Str. 27, 18051 Rostock, Germany.
Hendryk CzechInstitute of Chemistry, University of Rostock, Albert-Einstein Str. 27, 18051 Rostock, Germany.ORCID 0000-0001-8377-4252
Sebastiano di BucchianicoInstitute of Chemistry, University of Rostock, Albert-Einstein Str. 27, 18051 Rostock, Germany.ORCID 0000-0002-6396-892X
Thorsten StreibelInstitute of Chemistry, University of Rostock, Albert-Einstein Str. 27, 18051 Rostock, Germany.ORCID 0000-0002-0221-2125
Mathilde N DelavalComprehensive Molecular Analytics (CMA), Helmholtz Zentrum München, 85764 Neuherberg, Germany.ORCID 0000-0002-1340-5336
Christopher RugerInstitute of Chemistry, University of Rostock, Albert-Einstein Str. 27, 18051 Rostock, Germany.
Nathalie BaumlinDepartment of Internal Medicine, University of Kansas Medical Centre, Kansas City, KS 66160, USA.ORCID 0000-0002-5341-6785
Matthias SalatheDepartment of Internal Medicine, University of Kansas Medical Centre, Kansas City, KS 66160, USA.ORCID 0000-0001-9092-4861
Zheng FangDepartment of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-2355-5618
Michal PardoDepartment of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-6480-1171
Sara D'AroncoYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Chiara GiorioYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0001-7821-7398
Zongbo ShiDivision of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B1 52TT, UK.ORCID 0000-0002-7157-543X
Roy M HarrisonDivision of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B1 52TT, UK.ORCID 0000-0002-2684-5226
David C GreenMRC Centre for Environment and Health, Environmental Research Group, Imperial College London, 86 Wood Lane, London W12 0BZ, UK.ORCID 0000-0002-0695-4660
Frank J KellyMRC Centre for Environment and Health, Environmental Research Group, Imperial College London, 86 Wood Lane, London W12 0BZ, UK.ORCID 0000-0003-2558-8392
Yinon RudichDepartment of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-3149-0201
Suzanne E PaulsonDepartment of Atmospheric and Oceanic Sciences, University of California at Los Angeles, 405 Hilgard Ave, Portola Plaza, Los Angeles, CA 90095-1565, USA.ORCID 0000-0003-0855-7615
Olli SippulaDepartment of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.ORCID 0000-0002-6981-2694
Ralf ZimmermannInstitute of Chemistry, University of Rostock, Albert-Einstein Str. 27, 18051 Rostock, Germany.
Marianne GeiserInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-4288-7995
Markus KalbererDepartment of Environmental Sciences, University of Basel, Klingelbergstrasse 27, 4056 Basel, Switzerland.ORCID 0000-0001-8885-6556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to airborne particulate matter (PM) has been attributed to millions of deaths annually. However, the PM components responsible for observed health effects remain unclear. Oxidative potential (OP) has gained increasing attention as a key property that may explain PM toxicity. Using online measurement methods that impinge particles for OP quantification within seconds, we reveal that 60 to 99% of reactive oxygen species (ROS) and OP in secondary organic aerosol and combustion-generated PM have a lifetime of minutes to hours and that the ROS activity of ambient PM decays substantially before offline analysis. This implies that current offline measurement methods substantially underestimate the true OP of PM. We demonstrate that short-lived OP components activate different toxicity pathways upon direct deposition onto reconstituted human bronchial epithelia. Therefore, we suggest that future air pollution and health studies should include online OP quantification, allowing more accurate assessments of links between OP and health effects.

Indexed as

Air PollutantsParticulate MatterReactive Oxygen SpeciesAerosolsHumansOxidation-ReductionOxidative StressParticle SizeAerosolsAir PollutantsParticulate MatterReactive Oxygen Species

Identifiers

PMID40106561
PMCPMC11922065

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.