ArticleScience advances2025
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Article
- Article
- Ligand Binding Dynamics of Ion Channels and GPCRs Using Single-Molecule Fluorescence.Annual review of biophysics · 2026Review
- A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors.Scientific reports · 2026Article
- CH25H-mediated cholesterol metabolism drives chondrogenic differentiation in adipose-derived stem cells and enhances cartilage repair.Communications biology · 2026Article
- Signaling Bias as a Framework for Therapeutically Relevant Orthosteric Agonists: The βBiochemistry · 2026Article
- Unraveling allosteric signaling of G protein-coupled receptors (GPCRs) by single-molecule fluorescence.Biophysical reviews · 2026Review
- Article
- Mechanistic insights into the therapeutic properties of delta opioid receptor.Science advances · 2026Article
- Revealing the multiple faces of LRG1: gene expression, structure, function, and therapeutic potential.Journal of advanced research · 2026Review
- Designing Rigid Protein Fiducials to Visualize GPCR Conformational States.bioRxiv : the preprint server for biology · 2026Article
- CW ESR spectroscopy and protein spin labeling in membrane biology.Physical biology · 2025Review
- Type-1 Cannabinoid Receptor Promiscuous Coupling: Computational Insights into Receptor-G Protein Interaction Dynamics.International journal of molecular sciences · 2025Article
- Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025Review
- A biased allosteric modulator functions as a molecular glue to induce βResearch square · 2025Article
- Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Conformational Heterogeneity Underlying Divergent Signaling in Class A G Protein-Coupled Receptors.ACS pharmacology & translational science · 2025Review
- Elucidating zerumbone's low-efficacy agonism at the μ-opioid receptor via molecular dynamics simulation and Markov state modeling.Journal of computer-aided molecular design · 2025Article
- A biased allosteric modulator functions as a molecular glue to induce βbioRxiv : the preprint server for biology · 2025Article
- Recent advances in quantifying protein conformational ensembles with dipolar EPR spectroscopy.Current opinion in structural biology · 2025Review
Corrections and comments
- Erratum issued
- Update of
Authors and funding
23 authors.
Marina CasiraghiDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0627-2288
Haoqing WangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0277-3018
Patrick C BrennanDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-6287-7551
Chris HabrianDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Harald HübnerDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-7892-599X
Maximilian F SchmidtDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-7055-2439
Luis MaulDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-0513-3158
Biswaranjan PaniDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-4811-4632
Sherif M F M BahrizDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-9310-8349
Bing XuDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.
Nico StaffenDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Tufa E AssafaDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0003-2352-685X
Bohan ChenDepartment of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.ORCID 0009-0002-3834-8048
Elizabeth WhiteDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Roger K SunaharaDepartment of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0003-1702-8619
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.ORCID 0000-0003-0805-4049
Yang K XiangDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-1786-9143
Robert J LefkowitzDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-1472-7545
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Nathaniel NucciDepartment of Physics and Astronomy and Department of Biological and Biomedical Biosciences, Rowan University, Glassboro, NJ, USA.ORCID 0000-0001-8034-4492
Peter GmeinerDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-4127-197X
Michael T LerchDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-8173-4879
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5958-3990
Funding
Structure and dynamics of G protein coupled receptor-G protein complexesR01GM083118 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOBILKA, BRIAN K, SKINIOTIS, GEORGIOS · 2008 to 2023
$8.3MTHE MECHANISM OF BETA2 ADRENOCEPTOR ACTIVATIONR01NS028471 · NINDS · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 1990 to 2021
$6.7MPhosphodiesterases govern nuclear cAMP signaling for gene expressionR01MH134119 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG Kevin XIANG · 2023 to 2026
$2.6MRegulation of a cardiac b1AR/SERCA2 complex in heart failureR01HL162825 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG KEVIN · 2022 to 2025
$2.5MRegulation of β2-adrenergic receptor signaling by post-translational modificationsR01GM135581 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI LERCH, MICHAEL TAYLOR · 2019 to 2023
$1.7MConformational mechanisms of mGluR gating and regulationR01NS119826 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2021 to 2024
$1.6MUpgrade of a Pulsed Electron Paramagnetic Resonance SpectrometerS10OD024980 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2018 to 2018
$1.5MUpgrades to a Bruker Q-band E580 Pulse EPR SpectrometerS10OD025260 · OD · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2019 to 2019
$478kStructural basis for regulation of beta2 adrenergic receptor signaling by the dynamic post-translational modification S-palmitoylationF31HL164002 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BRENNAN, PATRICK C · 2023 to 2024
$97kBLRD VA I01 BX005100BLRD VA IK6 BX005753NHLBI NIH HHS F31 HL164002NHLBI NIH HHS R01 HL162825NIGMS NIH HHS R01 GM083118NIGMS NIH HHS R01 GM135581NIH HHS S10 OD024980NIH HHS S10 OD025260NIMH NIH HHS R01 MH134119NINDS NIH HHS R01 NS028471NINDS NIH HHS R01 NS119826
Abstract
G protein-coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR-G protein complexes, little is known about the mechanism of G protein coupling specificity. The β
Indexed as
GTP-Binding ProteinsReceptors, Adrenergic, beta-2Receptors, G-Protein-CoupledGTP-Binding Protein alpha Subunits, GsHEK293 CellsHumansLigandsModels, MolecularProtein BindingProtein ConformationSignal TransductionGTP-Binding Protein alpha Subunits, GsGTP-Binding ProteinsLigandsReceptors, Adrenergic, beta-2Receptors, G-Protein-Coupled
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