Evidence map›Paper›PMID 40106545›Full record

ArticleScience advances2025

Structural basis for the substrate recognition and transport mechanism of the human y

Lu Dai, Qian Zeng, Ting Zhang, Yuanyuan Zhang, Yi Shi, Yaning Li, Kangtai Xu, Jing Huang, Zilong Wang, Qiang Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lu DaiSchool of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID 0009-0001-0330-7994
Qian ZengSchool of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID 0009-0000-8001-5752
Ting ZhangSchool of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID 0009-0003-0124-6758
Yuanyuan ZhangResearch Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, China.ORCID 0000-0002-2500-0010
Yi ShiResearch Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, China.ORCID 0000-0002-6281-8911
Yaning LiBeijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-3245-3023
Kangtai XuSchool of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID 0009-0006-8462-6212
Jing HuangResearch Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, China.ORCID 0000-0001-9639-2907
Zilong WangSchool of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID 0000-0001-7473-0354
Qiang ZhouResearch Center for Industries of the Future, Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, China.ORCID 0000-0002-6237-8813
Renhong YanSchool of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.ORCID 0000-0002-7122-6547

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heteromeric amino acid transporters (HATs), including y

Indexed as

Amino Acid Transport System y+LFusion Regulatory Protein 1, Heavy ChainBiological TransportCryoelectron MicroscopyHumansMolecular Dynamics SimulationMutationProtein BindingProtein ConformationSubstrate SpecificityAmino Acid Transport System y+LFusion Regulatory Protein 1, Heavy Chain

Identifiers

PMID40106545
PMCPMC11922002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.