ArticlePLoS biology2025
The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques.
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Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future.Investigative ophthalmology & visual science · 2026Review
- Spatial proteomic mapping of the human and mouse retina using IBEX.JCI insight · 2026Article
- Spatial proteomics in precision medicine: technologies, bioinformatics, and translational applications.Precision clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors.
Andrea J RadtkeLymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.ORCID https://orcid.org/0000-0003-4379-8967
Ifeanyichukwu U AnidiCritical Care Medicine and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Leanne ArakkalLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Armando J Arroyo-MejiasLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Rebecca T BeuschelLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Katy BörnerDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.
Colin J ChuUCL Institute of Ophthalmology and NIHR Moorfields Biomedical Research Centre, London, United Kingdom.
Beatrice ClarkLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Menna R ClatworthyMolecular Immunity Unit, Laboratory of Molecular Biology, Cambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge Department of Medicine, Cambridge, United Kingdom.
Jake ColauttiDepartment of Medicine, McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Fabian CosciaMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Spatial Proteomics Group, Berlin, Germany.
Joshua CroteauDepartment of Business Development, BioLegend Inc., San Diego, California, United States of America.
Saven DenhaDepartment of Medicine, McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Rose DeverFunctional Immunogenomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Walderez O DutraLaboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Sonja FritzscheMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Spatial Proteomics Group, Berlin, Germany.
Spencer FullamDivision of Rheumatology, Rush University Medical Center, Chicago, Illinois, United States of America.
Michael Y GernerDepartment of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America.
Anita GolaRobin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, United States of America.
Kenneth J GollobCenter for Research in Immuno-oncology (CRIO), Hospital Israelita Albert Einstein, São Paulo, Brazil.
Jonathan M HernandezSurgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Jyh Liang HorLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Hiroshi IchiseLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Zhixin JingLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Danny JonigkInstitute of Pathology, Aachen Medical University, RWTH Aachen, Aachen, Germany.
Evelyn KandovLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Wolfgang KastenmüllerWürzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Joshua F E KoenigDepartment of Medicine, McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Rosa K KortekaasDepartment of Medicine, McMaster University, Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada.
Aanandita KothurkarUCL Institute of Ophthalmology and NIHR Moorfields Biomedical Research Centre, London, United Kingdom.
Alexandra Y KreinsInfection Immunity and Inflammation Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Ian T LambornLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Yuri LinSurgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Katia Luciano Pereira MoraisCenter for Research in Immuno-oncology (CRIO), Hospital Israelita Albert Einstein, São Paulo, Brazil.
Aleksandra LunichCritical Care Medicine and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Jean C S LuzViral Vector Laboratory, Cancer Institute of São Paulo, University of São Paulo, São Paulo, Brazil.
Ryan B MacDonaldUCL Institute of Ophthalmology and NIHR Moorfields Biomedical Research Centre, London, United Kingdom.
Chen MakranzNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Vivien I MaltezDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.
John E McDonoughDepartment of Medicine, McMaster University, Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada.
Ryan V MoriartyDepartment of Cellular and Developmental Biology, Northwestern University, Chicago, Illinois, United States of America.
Juan M Ocampo-GodinezInfection Immunity and Inflammation Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Vitoria M OlynthoDepartment of Medicine, McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Annette OxeniusInstitute of Microbiology, ETH Zurich, Zurich, Switzerland.
Kartika PadhanLymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Kirsten RemmertSurgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Nathan RichozMolecular Immunity Unit, Laboratory of Molecular Biology, Cambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge Department of Medicine, Cambridge, United Kingdom.
Edward C SchromLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Wanjing ShangLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Lihong ShiLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Rochelle M ShihLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Emily SperanzaFlorida Research and Innovation Center, Cleveland Clinic Lerner Research Institute, Port Saint Lucie, Florida, United States of America.
Salome StierliInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Sarah A TeichmannCambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Tibor Z VeresLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Megan VierhoutDepartment of Medicine, McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Brianna T WachterLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Adam K Wade-VallanceLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Margaret WilliamsCritical Care Medicine and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Nathan ZanggerInstitute of Microbiology, ETH Zurich, Zurich, Switzerland.
Ronald N GermainLymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Ziv YanivBioinformatics and Computational Bioscience Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Funding
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6MMultiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4MSenNet Supplement - Consortium BenchmarkingU24CA268108 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Philip D. Blood, JONATHAN C. SILVERSTEIN · 2021 to 2026
$22.1MConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI KRETZLER, MATTHIAS · 2017 to 2021
$21.0MFunctional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4MKPMP Kidney Mapping and Atlas Project (KMAP)U01DK133090 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$10.4M3D Multiscale Biomolecular Human Reference Atlas Construction, Visualization and Usage [4 of 5]OT2OD033756 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI BORNER, KATY · 2022 to 2025
$7.4MTRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6MThe Roles of Lymphoid Tissue Microenvironments in Guiding the Immune ResponseR01AI134713 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gerner · 2018 to 2026
$4.4MNational Institute of Diabetes and Digestive and Kidney Diseases ATLAS (D2K-ATLAS) Center as an accessible, comprehensive data portfolio for renal and genitourinary development and diseaseU24DK135157 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI JAIN, SANJAY, VALERIUS, MICHAEL TODD · 2022 to 2023
$3.4MThe Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and PainR01AR077019 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Rachel Elizabeth Miller · 2021 to 2026
$2.7MMultiplex imaging in therapy refractory tumors: understanding the spatiotemporal facets of an immunosuppressive environmentR00GM147841 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vivien Ileana Maltez · 2024 to 2026
$746kIntramural NIH HHS ZIA AI000545Intramural NIH HHS ZIA AI000758NCI NIH HHS U24 CA268108NIAID NIH HHS 75N93019C00070NIAID NIH HHS R01 AI134713NIAID NIH HHS T32 AI007476NIAMS NIH HHS R01 AR077019NIDDK NIH HHS U01 DK133090NIDDK NIH HHS U24 DK135157NIDDK NIH HHS U2C DK114886NIGMS NIH HHS R00 GM147841NIH HHS OT2 OD033756Wellcome Trust
Abstract
Multiplexed imaging is a powerful approach in spatial biology, although it is complex, expensive and labor-intensive. Here, we present the IBEX Knowledge-Base, a central resource for reagents, protocols and more, to enhance knowledge sharing, optimization and innovation of spatial proteomics techniques.
Indexed as
Knowledge BasesProteomicsHumans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.