Evidence map›Paper›PMID 40106432›Full record

ArticleCell reports2025

Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria.

Gunner P Johnston, Fikret Aydemir, Haewon Byun, Emmie de Wit, Kristie L Oxford, Jennifer E Kyle, Jason E McDermott, Brooke L Deatherage Kaiser, Cameron P Casey, Karl K Weitz and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Gunner P JohnstonDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Fikret AydemirDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Haewon ByunDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Emmie de WitLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
Kristie L OxfordEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Jennifer E KyleEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Jason E McDermottEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.
Brooke L Deatherage KaiserNational Security Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Cameron P CaseyEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Karl K WeitzEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Heather M OlsonEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Kelly G StrattonEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Natalie C HellerNational Security Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Viraj UpadhyeDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
I Abrrey MonrealDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
J Lizbeth Reyes ZamoraDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Lei WuDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
D H GoodallDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
David W BuchholzDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Joeva J BarrowDivision of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, NY 14853, USA.
Katrina M WatersEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Ruth N CollinsDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Heinz FeldmannLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
Joshua N AdkinsEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99354, USA. Electronic address: joshua.adkins@pnnl.gov.
Hector C AguilarDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: ha363@cornell.edu.

Funding

Mechanisms of Nipah virus fusion and entryR01AI109022 · NIAID · WASHINGTON STATE UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2014 to 2024
$4.3M
NIAID NIH HHS R01 AI109022
6 · The paper itself

Abstract

The recent global pandemic illustrates the importance of understanding the host cellular infection processes of emerging zoonotic viruses. Nipah virus (NiV) is a deadly zoonotic biosafety level 4 encephalitic and respiratory paramyxovirus. Our knowledge of the molecular cell biology of NiV infection is extremely limited. This study identified changes in cellular components during NiV infection of human cells using a multi-platform, high-throughput transcriptomics, proteomics, lipidomics, and metabolomics approach. Remarkably, validation via multi-disciplinary approaches implicated viral glycoproteins in enriching mitochondria-associated proteins despite an overall decrease in protein translation. Our approach also allowed the mapping of significant fluctuations in the metabolism of glucose, lipids, and several amino acids, suggesting periodic changes in glycolysis and a transition to fatty acid oxidation and glutamine anaplerosis to support mitochondrial ATP synthesis. Notably, these analyses provide an atlas of cellular changes during NiV infections, which is helpful in designing therapeutics against the rapidly growing Henipavirus genus and related viral infections.

Indexed as

GlycoproteinsHenipavirus InfectionsMitochondriaNipah VirusViral ProteinsHumansMetabolomicsProteomicsGlycoproteinsViral ProteinsCP: MicrobiologyhostinfectionlipidomicsmetabolismmetabolomicsNipah virusomicsparamyxovirusproteomicstranscriptomics

Identifiers

PMID40106432
PMCPMC12100452

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.