Evidence map›Paper›PMID 40106412›Full record

ArticlePloS one2025

Friendship Bench intervention to address depression and improve HIV care engagement among adolescents living with HIV in Malawi: Study protocol for a pilot randomized controlled trial.

Thuy Thi Dieu Dao, Bradley N Gaynes, Brian W Pence, Steven M Mphonda, Kazione Kulisewa, Michael Udedi, Melissa A Stockton, Jack Kramer, Katherine Grace Waddell, Maria Faidas and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06173544 (HIV Engagement and Adolescent Depression Support), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06173544 nacompletednot on this map

HIV Engagement and Adolescent Depression Support (HEADS-UP)

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2025Enrolled106ConditionsDepression, Anxiety, Adolescent Behavior, HIV InfectionsArmsStandard of Care (SOC), Adapted Friendship Bench (AFB), Enhanced Friendship Bench (EFB)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Thuy Thi Dieu DaoDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-2633-110X
Bradley N GaynesDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brian W PenceDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Steven M MphondaUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Kazione KulisewaDepartment of Mental Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Michael UdediNCDs & Mental Health Division, Malawi Ministry of Health, Lilongwe, Malawi.
Melissa A StocktonDepartment of Psychiatry, University of Pennsylvania, Philadelphia, USA.
Jack KramerDepartment of Mental Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Katherine Grace WaddellUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Maria FaidasDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Hillary MortensenDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Nivedita L BhushanCenter for Communication and Engagement Research, RTI International, Research Triangle Park, North Carolina, USA.

Funding

Improving HIV and Depression Outcomes by Reducing HIV-Mental Illness Stigma in Malawi: a pilot effectiveness-implementation trialK01MH130226 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa Ann Stockton · 2022 to 2026
$883k
HIV Engagement and Adolescent Depression Support (HEADS-UP)R34MH130232 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BHUSHAN, NIVEDITA L, GAYNES, BRADLEY N · 2022 to 2024
$727k
NIMH NIH HHS K01 MH130226NIMH NIH HHS R34 MH130232
6 · The paper itself

Abstract

backgroundAdolescents in Sub-Saharan Africa are disproportionately affected by the HIV epidemic. Comorbid depression is prevalent among adolescents living with HIV (ALWH) and poses numerous challenges to HIV care engagement and retainment. We present a pilot trial designed to investigate feasibility, fidelity, and acceptability of an adapted and an enhanced Friendship Bench intervention (henceforth: AFB and EFB) in reducing depression and improving engagement in HIV care among ALWH in Malawi.

methodsDesign: Participants will be randomized to one of three conditions: the Friendship Bench intervention adapted for ALWH (AFB, n = 35), the Friendship Bench intervention enhanced with peer support (EFB, n = 35), or standard of care (SOC, n = 35). Recruitment is planned for early 2024 in four clinics in Malawi. Participants: Eligibility criteria (1) aged 13-19; (2) diagnosed with HIV (vertically or horizontally); (3) scored ≥  13 on the self-reported Beck's Depression Inventory (BDI-II); (4) living in the clinic's catchment area with intention to remain for at least 1 year; and (5) willing to provide informed consent. Interventions: AFB includes 6 counseling sessions facilitated by young, trained non-professional counselors. EFB consists of AFB plus integration of peer support group sessions to facilitate engagement in HIV care. SOC for mental health in public facilities in Malawi includes options for basic supportive counseling, medication, referral to mental health clinics or psychiatric units at tertiary care hospitals for more severe cases. Outcomes: The primary outcomes are feasibility, acceptability, and fidelity of the AFB and EFB assessed at 6 months and 12 months and compared across 3 arms. The secondary outcome is to assess preliminary effectiveness of the interventions in reducing depressive symptoms and improving HIV viral suppression at 6 months and 12 months. DISCUSSION: This pilot study will provide insights into youth-friendly adaptations of the Friendship Bench model for ALWH in Malawi and the value of adding group peer support for HIV care engagement. The information gathered in this study will lead to a R01 application to test our adapted intervention in a large-scale cluster randomized controlled trial to improve depression and engagement in HIV care among ALWH.

trial registrationClinicalTrials.gov (NCT06173544).

Indexed as

DepressionFriendsHIV InfectionsAdolescentFemaleHumansMalawiMalePeer GroupPilot ProjectsSocial SupportYoung Adult

Identifiers

PMID40106412
PMCPMC11922207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.