Evidence map›Paper›PMID 40106360›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoclastogenesis.

Wei Zhang, Wenming Li, Jun Du, Chen Yang, Lei Yu, Peng Yang, Haifeng Zhang, Zebin Wu, Gaoran Ge, Huilin Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei Zhang *Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Wenming Li *Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Jun Du *Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Chen YangDepartment of Orthopaedics, Huaian Hospital Affiliated to Yangzhou University, Huaian, Jiangsu 223300, China.
Lei YuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Peng YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Haifeng ZhangDepartment of Orthopaedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Zebin WuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Gaoran GeDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
Dechun GengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.ORCID 0000-0003-1425-2535

Funding

Natural Science Foundation for Young Scientists of Shanxi Province (Young Scientists Fund of the National Natural Science Foundation of China) 82072425 82072498 82272567
6 · The paper itself

Abstract

Redox imbalance contributes to aberrant osteoclastogenesis and osteoporotic bone loss. In this study, we observed lower Forkhead box protein O3 (FoxO3), a transcription factor associated with cellular oxidative stress, enhanced osteoclastogenesis in osteoporosis (OP). Single-cell RNA sequencing (scRNA-seq) analysis on the human femoral head indicated that FoxO3 is widely expressed in macrophages. Furthermore, Lysm-Cre;FoxO3

Indexed as

DNA (Cytosine-5-)-MethyltransferasesDNA MethylationForkhead Box Protein O3OsteoclastsOsteogenesisOsteoporosisAnimalsDNA Methyltransferase 3AFemaleHumansMacrophagesMiceMice, Inbred C57BLOxidation-ReductionOxidative StressPromoter Regions, GeneticDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseForkhead Box Protein O3FOXO3 protein, humanFoxO3 protein, mouseReactive Oxygen SpeciesDNA methylationDnmt3aFoxO3osteoclastogenesisredox imbalance

Identifiers

PMID40106360
PMCPMC11962505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.