Evidence map›Paper›PMID 40106328›Full record

ArticleeLife2025

Integration of sensory and fear memories in the rat medial temporal lobe.

Francesca S Wong, Alina B Thomas, Simon Killcross, Vincent Laurent, R Fred Westbrook, Nathan M Holmes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The next generation of fear generalization.Trends in cognitive sciences · 2026
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca S WongSchool of Psychology, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-8533-9833
Alina B ThomasSchool of Psychology, University of New South Wales, Sydney, Australia.
Simon KillcrossSchool of Psychology, University of New South Wales, Sydney, Australia.
Vincent LaurentSchool of Psychology, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0003-2333-8437
R Fred WestbrookSchool of Psychology, University of New South Wales, Sydney, Australia.
Nathan M HolmesSchool of Psychology, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-0592-2026

Funding

Australian Research Council DP190100747Australian Research Council FT190100697
6 · The paper itself

Abstract

Wong et al., 2019 used a sensory preconditioning protocol to examine how sensory and fear memories are integrated in the rat medial temporal lobe. In this protocol, rats integrate a sound-light (sensory) memory that forms in stage 1 with a light-shock (fear) memory that forms in stage 2 to generate fear responses (freezing) across test presentations of the sound in stage 3. Here, we advance this research by showing that (1) how/when rats integrate the sound-light and light-shock memories (online in stage 2 or at test in stage 3) changes with the number of sound-light pairings in stage 1; and (2) regardless of how/when it occurs, the integration requires communication between two regions of the medial temporal lobe: the perirhinal cortex and basolateral amygdala complex. Thus, 'event familiarity' determines how/when sensory and fear memories are integrated but not the circuitry by which the integration occurs: this remains the same.

Indexed as

FearMemoryTemporal LobeAnimalsBasolateral Nuclear ComplexMalePerirhinal CortexRatsamygdalafear conditioningintegrationmemoryneuroscienceperirhinal cortexratsensory preconditioning

Identifiers

PMID40106328
PMCPMC11922503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.