Evidence map›Paper›PMID 40106212›Full record

ArticleJapanese journal of radiology2025

Prediction of the wall-invasion pattern of advanced gallbladder carcinoma using extracellular volume fraction.

Yukihisa Takayama, Takehiko Koga, Yoshihiro Hamada, Shinji Tanaka, Keisuke Sato, Ryo Murayama, Yusuke Ishida, Masatoshi Kajiwara, Kengo Yoshimitsu

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Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yukihisa TakayamaDepartment of Radiology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan. ytakayama@fukuoka-u.ac.jp.ORCID http://orcid.org/0000-0002-2029-9316
Takehiko KogaDepartments of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Yoshihiro HamadaDepartment of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Shinji TanakaDepartment of Radiology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Keisuke SatoDepartment of Radiology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Ryo MurayamaDepartment of Radiology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Yusuke IshidaDepartments of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Masatoshi KajiwaraDepartment of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.
Kengo YoshimitsuDepartment of Radiology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the utility of extracellular volume (ECV) fraction for predicting wall-invasion patterns in advanced gallbladder carcinoma (GBCA). MATERIALS AND

methodsPatients who had surgically resected GBCA at a single institution were retrospectively evaluated. All patients underwent computed tomography (CT) before the surgery. Based on pathological examinations, the wall-invasion pattern of GBCA was classified into two groups: infiltrative growth (IG, n = 19) and destructive growth (DG, n = 11). ECV map was generated by inputting the patients' hematocrit values and subtraction algorithms using pre-contrast and equilibrium phase images. CT parameters were evaluated by two radiologists (Rad1 and Rad2). The Mann-Whitney U test was performed to identify significant CT parameters for differentiating between the two groups. The diagnostic ability was measured using receiver operating characteristic (ROC) curve analysis. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method, and differences between the two groups were compared using the log-rank test.

resultsThirty patients (mean age, 75.5 years; 20 men) were evaluated. Mean ECV fraction of the DG-type (Rad1, 34.5%; Rad2, 34.1%) was significantly higher than that of the IG-type (Rad1, 28.5%; Rad2, 28.8%) (p < 0.05). The ECV values of the two radiologists indicated that the areas under the ROC curves for differentiation between the two groups were Rad1, 0.91 and Rad2, 0.84 (p < 0.05). Medium RFS of the DG-type (970 days) was significantly shorter than that of the IG-type (2200 days) (p < 0.05).

conclusionECV fraction demonstrates potential as the most valuable predictor of the DG type of GBCA, which has a higher recurrence rate compared with the IG type. However, further large-scale multi-center studies are required to validate these findings.

Indexed as

Gallbladder NeoplasmsTomography, X-Ray ComputedAgedAged, 80 and overFemaleGallbladderHumansMaleMiddle AgedNeoplasm InvasivenessPredictive Value of TestsRetrospective StudiesComputed tomographyDesmoplastic reactionExtracellular volume fractionGallbladder carcinomaWall-invasion type

Identifiers

PMID40106212
PMCPMC12287180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.