Evidence map›Paper›PMID 40106116›Full record

ArticleEuropean journal of epidemiology2025

Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization.

Tom G Richardson, Helena Urquijo, Laurence J Howe, Gareth Hawkes, John DePaolo, Scott M Damrauer, Timothy M Frayling, George Davey Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tom G RichardsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK. Tom.G.Richardson@bristol.ac.uk.ORCID http://orcid.org/0000-0002-7918-2040
Helena UrquijoMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.ORCID http://orcid.org/0000-0001-7549-6782
Laurence J HoweMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.ORCID http://orcid.org/0000-0002-2819-9686
Gareth HawkesGenetics of Complex Traits, College of Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, Devon, UK.ORCID http://orcid.org/0000-0002-3367-789X
John DePaoloDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-6829-2594
Scott M DamrauerDivision of Vascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0001-8009-1632
Timothy M FraylingDepartment of Genetic Medicine and Development, Faculty of Medicine, CMU, Geneva, Suisse.ORCID http://orcid.org/0000-0001-8362-2603
George Davey SmithMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314

Funding

Medical Research Council MC_UU_00011/1
6 · The paper itself

Abstract

Taller individuals are at elevated and protected risk of various cardiovascular disease endpoints. Whether this is due to a direct consequence of their height during childhood, a long-term effect of remaining tall throughout the lifecourse, or confounding by other factors, is unknown. We sought to address this by harnessing human genetic data from the UK Biobank to separate the independent effects of childhood and adulthood height using an approach known as lifecourse Mendelian randomization (MR). Protective effects of taller childhood height on risk of later life coronary artery disease (OR = 0.78 per change in height category, 95% CI = 0.70 to 0.86, P = 4 × 10

Indexed as

Body HeightCardiovascular DiseasesMendelian Randomization AnalysisAdultAgedChildCoronary Artery DiseaseFemaleHumansMaleMiddle AgedRisk FactorsStrokeUnited KingdomALSPACChildhood heightLifecourse epidemiologyMendelian randomizationUK Biobank

Identifiers

PMID40106116
PMCPMC12018521

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.