ArticleEuropean radiology experimental2025
Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- T1 mapping in Alzheimer's disease: a quantitative MRI study with amyloid-PET correlation.European radiology experimental · 2026Article
- Impaired white matter functional networks topology changed with white matter hyperintensities burden and relationship to cognition.Brain imaging and behavior · 2026Article
- Radiomics-enhancedEuropean radiology experimental · 2026Article
- A pilot study on protocol consistency and graph metric reproducibility in microstructure-weighted connectomes.Scientific reports · 2026Article
- White matter abnormalities in amyotrophic lateral sclerosis: a free water imaging study.Frontiers in neuroscience · 2026Article
- Diffusion connectometry reveals white matter substrates of individual differences in loss aversion.Scientific reports · 2025Article
- Development and Validation of the Short-Form BrainOK: An Efficient Digital Screening Tool for Mild Cognitive Impairment.Diagnostics (Basel, Switzerland) · 2025Article
- Assessment of a diffusion phantom for quality assurance in brain microstructure diffusion MRI studies.Scientific reports · 2025Article
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Abstract
backgroundThe cingulum bundle is a brain white matter fasciculus associated with the cingulate gyrus. It connects areas from the temporal to the frontal lobe. It is composed of fibers with different terminations, lengths, and structural properties, related to specific brain functions. We aimed to automatically reconstruct this fasciculus in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) and to assess whether trajectories have different microstructural properties in relation to dementia progression.
methodsMulti-shell high angular resolution diffusion imaging-HARDI image datasets from the "Alzheimer's Disease Neuroimaging Initiative"-ADNI repository of 10 AD, 18 MCI, and 21 cognitive normal (CN) subjects were used to reconstruct three subdivisions of the cingulum bundle, using a probabilistic approach, combined with measurements of diffusion tensor and neurite orientation dispersion and density imaging metrics in each subdivision.
resultsThe subdivisions exhibit different pathways, terminations, and structural characteristics. We found differences in almost all the diffusivity metrics among the subdivisions (p < 0.001 for all the metrics) and between AD versus CN and MCI versus CN subjects for mean diffusivity (p = 0.007-0.038), radial diffusivity (p = 0.008-0.049) and neurite dispersion index (p = 0.005-0.049).
conclusionResults from tractography analysis of the subdivisions of the cingulum bundle showed an association in the role of groups of fibers with their functions and the variance of their properties in relation to dementia progression. RELEVANCE STATEMENT: The cingulum bundle is a complex tract with several pathways and terminations related to many cognitive functions. A probabilistic automatic approach is proposed to reconstruct its subdivisions, showing different microstructural properties and variations. A larger sample of patients is needed to confirm results and elucidate the role of diffusion parameters in characterizing alterations in brain function and progression to dementia. KEY POINTS: The microstructure of the cingulum bundle is related to brain cognitive functions. A probabilistic automatic approach is proposed to reconstruct the subdivisions of the cingulum bundle by diffusion-weighted images. The subdivisions showed different microstructural properties and variations in relation to the progression of dementia.
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