Evidence map›Paper›PMID 40106070›Full record

ArticleInflammation2025

SUCNR1 Deficiency Alleviates Liver Ischemia-Reperfusion Injury by Regulating Kupffer Cell Activation and Polarization Through the ERK/NF-κB Pathway in Mice.

Huan Yang, An Wei, Xinting Zhou, Zhiwei Chen, Yiheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Chronic succinate exposure does not cause liver injury.American journal of physiology. Endocrinology and metabolism · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huan Yang *Department of Anesthesiology, the First Affiliated Hospital, Hengyang Medical School, University of South China, 69 Chuanshan Road, Shigu District, Hengyang, 421001, Hunan Province, China.
An Wei *Department of Anesthesiology, the First Affiliated Hospital, Hengyang Medical School, University of South China, 69 Chuanshan Road, Shigu District, Hengyang, 421001, Hunan Province, China.
Xinting ZhouDepartment of Anesthesiology, the First Affiliated Hospital, Hengyang Medical School, University of South China, 69 Chuanshan Road, Shigu District, Hengyang, 421001, Hunan Province, China.
Zhiwei ChenDepartment of Anesthesiology, the First Affiliated Hospital, Hengyang Medical School, University of South China, 69 Chuanshan Road, Shigu District, Hengyang, 421001, Hunan Province, China.
Yiheng WangDepartment of Anesthesiology, the First Affiliated Hospital, Hengyang Medical School, University of South China, 69 Chuanshan Road, Shigu District, Hengyang, 421001, Hunan Province, China. wyheng11@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Succinate regulates inflammation through its receptor, succinate receptor 1 (SUCNR1). However, the effects of this interaction on Kupffer cell (KC)-driven inflammation during liver ischemia-reperfusion injury (IRI) remain unclear. Herein, we investigated the succinate/SUCNR1 axis in the progression of liver IRI. In this study, succinate levels and SUCNR1 expression were analyzed in mice underwent segmental liver IRI. Sucnr1 deficiency (Sucnr1

Indexed as

Kupffer CellsLiverMAP Kinase Signaling SystemNF-kappa BReceptors, G-Protein-CoupledReperfusion InjuryAnimalsApoptosisHepatocytesMaleMiceMice, Inbred C57BLMice, KnockoutGPR91 protein, mouseNF-kappa BReceptors, G-Protein-CoupledERK/NF-κB signaling pathwayInflammationKupffer cellLiver ischemia–reperfusion injurySuccinateSuccinate receptor 1

Identifiers

PMID40106070
PMCPMC12596356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.