ArticleClinical oral investigations2025
Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to evaluate the effects on morphology and permeability of dentin after an erosive and abrasive cycling protocol followed by treatment with an experimental solution containing dopamine. MATERIALS AND
methodsDentin hypersensitivity was simulated in human dentin discs by applying EDTA for 5 min. After assessing maximum dentin permeability (initial), specimens were randomly allocated into four groups: distilled water (control), NaF 0.05% solution, a commercial solution (Colgate
resultsA significant reduction in permeability occurred in all groups post-cycling and treatment (p < 0.05), with no significant differences between groups (p = 0.6082). All groups exhibited sparse surface deposits, with few occluded tubules. Tubules appeared smaller in diameter in the Colgate
conclusionIn this model, dopamine demonstrated a limited effect, showing no significant protection of the dentin surface or reduction in permeability, similar to the other tested solutions. CLINICAL RELEVANCE: Changes in the habits of modern society have increased the prevalence of tooth wear and dentin hypersensitivity. In this context, it is essential to develop not only new active ingredients to prevent or minimize mineral loss but also new treatment methods.
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