ArticleJournal of molecular histology2025
Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis via Bcl-2/Bax regulation.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Ameliorative effects of curcumin and resveratrol following abamectin-induced liver injury in rats.Scientific reports · 2026Article
- Integrated Molecular Docking and Network-Based Analysis Reveals Multitarget Interaction Patterns of Nutraceutical Compounds in Intervertebral Disc Degeneration.Biomedicines · 2026Article
- Curcumin treatment attenuates methotrexate-induced nephrotoxicity in rats by inhibiting inflammation and fibrosis.Journal of molecular histology · 2026Article
- Nanobacterial detection in aqueous humor and its effect on postphacoemulsification visual acuity among highly myopic patients.Molecular vision · 2026Article
- Review
- Bioactive metabolites of botanical drugs in the treatment of intervertebral disc degeneration-a review of promising therapeutic candidate.Frontiers in pharmacology · 2025Review
- Natural products for intervertebral disc degeneration: mechanistic insights and therapeutic potentials.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The study aims to investigate the protective effect of curcumin on intervertebral disc degeneration by examining its influence on IL-1β-induced apoptosis in rat cartilage endplate cells. The rat primary chondrocytes treated by IL-1 β at 10 ng /mL was utilized as a rat model in intervertebral disc degeneration, followed by incubation with different concentration of curcumin (10, 15, 20 μmol/L). Cell apoptosis and cell proliferation were conducted through flow cytometry and CCK-8, respectively. Furthermore, immunofluorescence staining was used to visualize the expression of Bax and Bcl-2 inside the cells. Western blotting was performed to determine the expression of the Bax and Bcl-2. Curcumin promoted proliferation of chondrocytes treated by IL-1 β, but inhibited the apoptosis. Importantly, curcumin significantly downregulated the expression level of Bax but upregulated the expression level of Bcl-2. Strengths of this study include the use of multiple assays to validate the findings, while limitations include the in vitro nature and lack of in vivo data. Curcumin is capable of ameliorating IL-1β -induced intervertebral disc degeneration by Bcl-1 and Bax production. This study provides a foundation for future research into curcumin's therapeutic potential in intervertebral disc degeneration.
Indexed as
Identifiers
40106034What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.