Evidence map›Paper›PMID 40106020›Full record

ArticleActa neurochirurgica2025

Comparative analysis of the lumboperitoneal shunt versus ventriculoperitoneal shunt for leptomeningeal metastasis-associated hydrocephalus in non-small cell lung cancer.

Minjoon Kim, Chaejin Lee, Sang-Youl Yoon, Seong-Hyun Park, Jeong-Hyun Hwang, Kyunghun Kang, Eunhee Park, Sunha Choi, Shin Yup Lee, Seung Soo Yoo and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Minjoon KimDepartment of Neurosurgery, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu, 700-422, Republic of Korea.
Chaejin LeeDepartment of Neurosurgery, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu, 700-422, Republic of Korea.
Sang-Youl YoonDepartment of Neurosurgery, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu, 700-422, Republic of Korea.
Seong-Hyun ParkDepartment of Neurosurgery, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu, 700-422, Republic of Korea.
Jeong-Hyun HwangDepartment of Neurosurgery, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu, 700-422, Republic of Korea.
Kyunghun KangDepartment of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea.
Eunhee ParkDepartment of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Sunha ChoiDivision of Pulmonology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Shin Yup LeeDivision of Pulmonology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Seung Soo YooDivision of Pulmonology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Yee Soo ChaeDepartment of Hemato/Oncology, School of Medicine, Kyungpook National University, Daegu, Korea.
Ki-Su ParkDepartment of Neurosurgery, School of Medicine, Kyungpook National University, 101 Dongin-dong 2 Ga, Jung-gu, Daegu, 700-422, Republic of Korea. kiss798@gmail.com.ORCID 0000-0002-4829-6299

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLeptomeningeal metastasis (LM)-associated hydrocephalus is a rare but severe complication of non-small cell lung cancer (NSCLC). The spread of malignant cells to the leptomeninges obstructs cerebrospinal fluid flow and increases intracranial pressure (ICP). This study compared the outcomes of lumboperitoneal (LP) and ventriculoperitoneal (VP) shunt surgeries in managing LM-associated hydrocephalus, focusing on symptom-free periods (SFPs) and overall survival (OS).

methodsA retrospective analysis was conducted on 43 NSCLC patients with LM-associated hydrocephalus who underwent shunt surgery between 2017 and 2024. Patients were classified into LP (n = 23) and VP (n = 20) groups. Clinical characteristics, surgical outcomes, and survival rates were analyzed using Kaplan-Meier survival and Cox regression analyses. Karnofsky performance status (KPS), increased intracranial pressure (IICP) symptoms, and postoperative epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment were evaluated for prognostic significance.

resultsNo significant difference was observed between VP and LP shunt surgeries regarding SFP (VP: 5.02 ± 1.29 months, LP: 7.50 ± 2.86 months, p = 0.906) or OS (VP: 8.43 ± 1.89 months, LP: 9.62 ± 3.20 months, p = 0.820). High preoperative KPS, absence of ICP symptoms, and postoperative EGFR-TKI treatment were significantly associated with improved SFP and OS (p < 0.05). LP shunt surgery had shorter anesthesia and fewer complications compared to VP shunt surgery, representing a viable option for patients unsuitable for general anesthesia.

conclusionLP and VP shunt surgeries are equally effective for patients with LM-associated hydrocephalus in NSCLC. LP shunt surgery under local anesthesia could be recommended for its safety and patient acceptability. Favorable prognostic factors, including high KPS, absence of ICP, and postoperative EGFR-TKI treatment, should guide individualized treatment strategies to enhance patient outcomes and quality of life.

Indexed as

Carcinoma, Non-Small-Cell LungCerebrospinal Fluid ShuntsHydrocephalusLung NeoplasmsMeningeal CarcinomatosisMeningeal NeoplasmsVentriculoperitoneal ShuntAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeCarcinomaHydrocephalusMeningeal carcinomatosisNon-small-cell lungVentriculoperitoneal shunt

Identifiers

PMID40106020
PMCPMC11922981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.