SynthesisJournal of neurology2025
Gray matter structural and functional brain abnormalities in Parkinson's disease: a meta-analysis of VBM and ALFF data.
Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Gastric-Selective Associations of Caudate Functional Connectivity with Gastrointestinal Rhythms in Parkinson's Disease: A Resting-State fMRI and Electrogastroenterography Study.Brain sciences · 2026Article
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Differentiating tremor-dominant parkinson's disease from essential tremor using neuromelanin- sensitive imaging and T1w/T2w ratio.NPJ Parkinson's disease · 2026Article
- Multimodal Imaging Investigation of the Dentato-Thalamo-Cortical Pathway in Friedreich's Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Sex-divergent intrinsic brain function in Parkinson's disease: elevated nigral fluctuations and premotor-visuospatial coupling in female patients.Frontiers in neuroscience · 2026Article
- Financial abilities in patients with Parkinson's disease and mild cognitive impairment: unveiling cognitive and neurofunctional correlates of basic and advanced financial skills.Frontiers in aging neuroscience · 2026Article
- Sex-specific gray matter underpinnings of anxiety and their mediating mechanisms inFrontiers in aging neuroscience · 2026Article
- Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients.Journal of pain research · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundPrevious studies based on resting-state functional imaging and voxel-based morphometry (VBM) have revealed structural and functional alterations in several brain regions in patients with Parkinson's disease (PD), but their results have been inconsistent. Furthermore, no studies have investigated specific and common functional and structural alterations in PD.
methodsThe whole-brain voxel-wise meta-analyses on the VBM and amplitude of low-frequency fluctuation (ALFF) studies were conducted using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software, respectively, with multimodal overlapping to comprehensively identify the gray matter volume (GMV) and spontaneous functional activity changes in patients with PD.
resultsA total of 30 independent studies for ALFF (1413 PD and 1424 HCs) and 27 independent studies for VBM (1236 PD and 1185 HCs) were included. Compared with HCs, patients with PD displayed significantly decreased spontaneous functional activity in the left striatum. For the VBM meta-analysis, patients with PD showed significantly decreased GMV in the right temporal pole: superior temporal gyrus (extending to the right hippocampus, parahippocampal gyrus, and amygdala), the left superior temporal gyrus (extending to the left insula, and temporal pole: superior temporal gyrus), and the left striatum. Furthermore, after overlapping functional and structural differences, patients with PD displayed a conjoint decrease of spontaneous functional activity and GMV in the left striatum.
conclusionThe multimodal meta-analysis revealed that PD showed similar pattern of aberrant brain functional activity and structure in the striatum. In addition, some brain regions within the within the temporal lobe and limbic system displayed only structural deficits. These findings provide useful insights for understanding the underlying pathophysiology of PD.
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