Design and optimization of a novel fluorescent molecularly imprinted polymer for selective niclosamide sensing in real samples: greenness assessment of MIP synthesis using AGREEMIP.

Kalyani A Birari, Pravin O Patil, Mohamad Taleuzzaman, Md Shamsher Alam, Shadma Wahab, Mohammad Khalid, Zamir G Khan

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Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Kalyani A BirariDepartment of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research Shirpur, Dist. Dhule, 425 405, Maharashtra, India.

Pravin O PatilDepartment of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research Shirpur, Dist. Dhule, 425 405, Maharashtra, India.

Mohamad TaleuzzamanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Maulana Azad University, Village Bujhawar, Tehsil Luni, Jodhpur, 342802, Rajasthan, India.

Md Shamsher AlamDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, 45142, Kingdom of Saudi Arabia.

Shadma WahabDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, 62529, Abha, Saudi Arabia.

Mohammad KhalidDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.

Zamir G KhanDepartment of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research Shirpur, Dist. Dhule, 425 405, Maharashtra, India. khanzamir.5588@gmail.com.ORCID 0000-0002-7649-9413

Funding

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6 · The paper itself

Abstract

In the fields of public health, veterinary medicine, and aquaculture, niclosamide (NIC), a common anthelmintic drug, is essential for deworming and treating a variety of illnesses, such as viral infections, metabolic disorders, and cancer. However, NIC can pose potential risks, such as DNA damage and adverse vasodilation effects in vivo. This study introduces an innovative fluorescent nanosensor for the detection of NIC in food samples. The sensor utilises sulphur and nitrogen co-doped carbon dots (S,N-CDs) derived from eco-friendly materials, Turbo bruneus and L-cysteine, encapsulated within a molecularly imprinted polymer (S,N-CDs@MIP). The sensor operates on a "Turn Off" mechanism, where NIC binding results in decreased fluorescence intensity, effectively detecting NIC in the 1-10 µM concentration range. Excellent sensitivity is indicated by the calibration curve, which displays a strong linear connection between NIC concentration and fluorescence intensity (Y = 0.0612x + 0.0689, R

Indexed as

Fluorescent DyesMolecular ImprintingMolecularly Imprinted PolymersNiclosamideAnimalsCarbonFood ContaminationLimit of DetectionQuantum DotsSpectrometry, FluorescenceCarbonFluorescent DyesMolecularly Imprinted PolymersNiclosamideCarbon quantum dotsFluorescent probeInner filter effectMolecularly imprinted polymersNiclosamide“off–on” fluorescent probe

Identifiers

PMID40106013

DOI10.1007/s00604-025-07090-4

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