ArticleMedical oncology (Northwood, London, England)2025
Isoliquiritigenin attenuates tumor progression and PD-L1 expression by inhibiting the phosphorylation of STAT3 in melanoma.
Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Differentiation state affects PD-L1 expression in cutaneous melanoma: a systematic review.Cellular & molecular biology letters · 2026Pooled it
- Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis.Journal of natural medicines · 2026Article
- Cancer cachexia as an immunometabolic syndrome: targeting the immunometabolic interface with traditional Chinese Medicine monomers and formulas.Frontiers in immunology · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
Isoliquiritigenin (ISL) has been reported with antitumor activities. While, the underlying molecular mechanisms remain largely unknown. The transcription factor of programmed cell death ligand 1 (PD-L1), STAT3, plays an important role in tumor metastasis. In this study, we first verified that ISL suppressed the growth and metastasis ability of melanoma cells both in vitro and in vivo. Then, we found that ISL could repress the expression of PD-L1 and STAT3 phosphorylation. TIMER algorithm analysis showed that the levels of immune infiltration were positively correlated with the expression of STAT3. Furthermore, the STAT3 phosphorylation inhibitor Stattic could enhance the effect of ISL in suppressing cell proliferation, promoting apoptosis, and restraining the ability of migration and invasion of melanoma cells. This study revealed that ISL inhibited melanoma metastasis and repressed PD-L1 expression by repressing the phosphorylation of STAT3, which help us to understand the mechanism of ISL in melanoma therapy.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.