ArticleLasers in medical science2025
The effect of photodynamic therapy using gentamicin and imipenem-derived carbon dots on Pseudomonas aeruginosa isolates.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026Review
- Effect of photodynamic therapy with imipenem and gentamicin-derived carbon dots on the expression of quorum sensing and virulence genes in Pseudomonas aeruginosa.BMC microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The increasing prevalence of antibiotic resistance poses a significant threat to the ability of healthcare systems to manage Pseudomonas aeruginosa infections, highlighting the need for innovative therapeutic strategies. The aim of this study was to evaluate the effects of photodynamic therapy (PDT) using carbon dots (CDs) derived from gentamicin and imipenem against P. aeruginosa isolates. A hydrothermal method was used to synthesise amine-functionalised CDs (CDsGEN-NH2, CDsIMP-NH2) from gentamicin and imipenem precursors, respectively. Conjugation of imipenem to CDsGEN-NH2 (CDsGEN-IMP) and gentamicin to CDsIMP-NH2 (CDsIMP-GEN) was achieved using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide. The synthesised CDs were analysed by HRTEM, zeta potential, UV-Vis, FTIR and fluorescence. The efficacy of photodynamic therapy (PDT) against P. aeruginosa ATCC27853 and two clinical P. aeruginosa isolates was evaluated using a combination of sub-minimum inhibitory concentrations (sub-MIC) and sub-lethal doses of UVA light (sDL) irradiation. The nanoscale size, electrical charge and photophysical properties of the synthesised CDs were confirmed by HRTEM, zeta potential, UV-Vis, FTIR and fluorescence techniques. Treatment with CDsGEN-NH2, CDsIMP-NH2 and CDsGEN-IMP at concentrations of 3 mg/mL (sub-MIC) and sDL irradiation for 10 s (3.12 J/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.