Evidence map›Paper›PMID 40105933›Full record

Observational studyPediatric nephrology (Berlin, Germany)2025

Dental caries, oral hygiene and salivary characteristics in children with chronic kidney disease: a case-control study.

Nur Kodaman Dokumacıgil, Berkant Sezer, Şehkar Oktay, Harika Alpay, Betül Kargül

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06578832 (Assessment of The Oral Health Status of Children With Chronic Kidney Disease), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06578832 completednot on this map

Assessment of The Oral Health Status of Children With Chronic Kidney Disease

Typeobservational_patient_registrySponsorMarmara UniversityRan2022 to 2024Enrolled167ConditionsChronic Kidney Diseases, Caries,Dental, Quality of Life, Saliva AlteredArmsphysical and chemical methods, biochemical methods, biochemical tests, Oral Health Habits, Oral Findings
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nur Kodaman DokumacıgilDepartment of Pediatric Dentistry, Faculty of Dentistry, Institute of Health Science, Marmara University, Istanbul, Türkiye. nurkodaman92@gmail.com.ORCID 0000-0002-1690-4499
Berkant SezerDepartment of Pediatric Dentistry, School of Dentistry, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.ORCID 0000-0001-9731-6156
Şehkar OktayDepartment of Biochemistry, School of Dentistry, Marmara University, Istanbul, Türkiye.ORCID 0000-0002-2878-288X
Harika AlpayDivision of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Türkiye.ORCID 0000-0002-0850-1964
Betül KargülDepartment of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Türkiye.ORCID 0000-0002-3294-8846

Funding

Marmara Üniversitesi TDK-2023-10958
6 · The paper itself

Abstract

backgroundThe aim of this study was to compare the oral health findings and salivary parameters of children with different stages of chronic kidney disease (CKD) with those of healthy peers.

methodsIntraoral examinations were performed on 43 children aged 8-17 years with CKD and 40 healthy controls from the same pediatric nephrology clinic. Oral health was assessed using the DMFT/dft indices (decayed-missing-filled-teeth), debris index (DI), calculus index (CI), and simplified oral hygiene index (OHI-S). Saliva samples from the children were analyzed for salivary flow rate (SFR), pH, buffering capacity (BC), total oxidant status (TOS), total antioxidant capacity (TAOC), urea, creatinine (Cr), calcium (Ca), potassium (K), phosphorus (P), and salivary α-amylase (SAA). Spearman's rho coefficient was used to examine the relationship between salivary and serum biomarkers levels and oral health findings.

resultsWhile the DMFT/dft scores were lower in children with CKD (p = 0.001), DI, CI, and OHI-S scores were higher in healthy peers (p < 0.001). Children with CKD had lower SFR, Ca, and TAOC levels, and higher BC, pH, urea, Cr, K, P, TOS, and SAA levels (p < 0.001) compared to healthy controls. Later stages of CKD was associated with the lower dft (

conclusionsChildren with CKD exhibit fewer caries and poorer oral hygiene compared to their healthy peers, and their saliva characteristics differ significantly from those of the healthy group. Disease-related changes in serum and salivary characteristics affect the oral health of children with CKD, necessitating collaboration between pediatric nephrologists and dentists.

trial registrationClinicalTrials.gov (NCT06578832).

Indexed as

Dental CariesOral HygieneRenal Insufficiency, ChronicSalivaAdolescentBiomarkersCase-Control StudiesChildDMF IndexFemaleHumansMaleOral HealthOral Hygiene IndexBiomarkersBiomarkersChildrenChronic kidney diseaseDental cariesOral hygieneSaliva

Identifiers

PMID40105933
PMCPMC12187895

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.