ArticleImmunity, inflammation and disease2025
Clinicopathological Characteristics and Outcomes of Lupus Nephritis Patients With Thrombocytopenia: A Single-Center Retrospective Study.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Kidney Biopsy and Prognosis in Lupus Nephritis: Histological Predictors of Renal Outcome-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
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8 authors.
Funding
Abstract
objectivesThe objective of this study is to analyze and summarize the clinical characteristics and prognosis of lupus nephritis (LN) patients with thrombocytopenia and to improve the cognition of the disease.
methods896 LN patients were enrolled in this study and their clinical and pathological data were collected and analyzed. The primary end point was mortality. The secondary end point was adverse renal outcomes, defined as doubling of the baseline serum creatinine or end-stage renal diseases. Cox regression model was used to analyze the risk factors of mortality or renal events in LN with and without thrombocytopenia.
resultsAmong 896 LN patients, 70 (7.8%) were diagnosed with thrombocytopenia. LN patients with thrombocytopenia had lower estimated glomerular filtration rate (eGFR) and higher systemic lupus erythematosus disease activity index (SLE-DAI), proportion of anemia, leukopenia, hypocomplementemia, and positive anti-cardiolipin antibodies, compared to those without thrombocytopenia. LN patients with thrombocytopenia had higher scores of activity index and more activity features (endocapillary hypercellularity, medullary loop necrosis) on kidney biopsy. There was no significant difference in patient survival and renal survival between LN patients with and without thrombocytopenia. Anemia was a risk factor for death in LN patients with thrombocytopenia and lower eGFR was a risk factor for adverse renal outcomes.
conclusionsLN patients with thrombocytopenia showed higher disease activity, more anti-cardiolipin antibody positivity and a higher activity index in kidney biopsy, but the prognosis was similar compared with those without thrombocytopenia. Anemia was a risk factor for death in LN patients with thrombocytopenia.
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