ArticleEuropean journal of neurology2025
Global, Regional, and National Burden of Early-Onset Alzheimer's Disease and Other Dementias in Young Adults Aged 40-64 Years, 1990-2021: A Population-Based Study.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Alzheimer's disease burden in China (ABC) study: protocol for a nationwide multicentre cross-sectional and prospective cohort study.BMJ open · 2026Article
- Promoting Effect of (+)-Borneol on Alzheimer's Disease Treatment in APP Transgenic Zebrafish and Its Blood-Brain Barrier Permeation Mechanism.Molecular neurobiology · 2026Article
- Assessing the risk of early-onset dementia within 5 years of cancer diagnosis Running Title: Early-onset dementia after cancer diagnosis.medRxiv : the preprint server for health sciences · 2026Article
- Nutritional strategies against dementia in rural populations.Frontiers in nutrition · 2025Review
- Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants.Frontiers in aging neuroscience · 2025Article
- Research progress in neuroimaging of sporadic early-onset Alzheimer's disease.Frontiers in neurologyReview
- Associations among mild behavioral impairment, cognition, and brain pathology in preclinical autosomal dominant Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Abstract
background and purposeEarly-onset Alzheimer's disease and other dementias (EOAD) impose significant burdens on affected individuals and their families. However, the global burden of EOAD has not been fully investigated. We aimed to assess the global, regional, and national burden of EOAD using data from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) study from 1990 to 2021.
methodsData for adults aged 40-64 were extracted within the GBD 2021 framework. Primary outcomes included age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) for EOAD, as well as average annual percentage change (AAPC) across 21 regions and 204 countries.
resultsIn 2021, EOAD cases reached 7.75 million (95% uncertainty interval [UI] 5.82-10.08), up from 3.67 million cases (95% UI 2.75-4.76) in 1990. The age-standardized prevalence rate increased from 341.2 per 100,000 (95% UI 255.89-442.79) in 1990 to 363.5 per 100,000 in 2021, with an AAPC of 0.26% (p < 0.001). EOAD prevalence was higher in women than in men in 2021 (4.28 million, 95% UI 3.24-5.56, vs. 3.46 million, 95% UI 2.57-4.52). EOAD was associated with 0.07 million (95% UI 0.01-0.23) deaths and 3.77 million (95% UI 1.69-8.88) DALYs in 2021. Additionally, 1.06 million (95% UI 0.07-3.03) DALYs were attributable to smoking, elevated fasting plasma glucose, and high body mass index.
conclusionsThe global number of EOAD cases among adults aged 40-64 years more than doubled from 1990 to 2021. Targeted strategies and interventions are urgently needed to address this growing public health issue.
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