Evidence map›Paper›PMID 40105211›Full record

ArticleCardiovascular research2025

Biologically engineered valved conduits for right ventricular outflow tract repair evaluated for 52 weeks in growing lambs.

Zeeshan H Syedain, Matthew Lahti, James Berry, John P Carney, Jill Schappa Faustich, Bee Haynie, Jack Maher, Richard Bianco, Gurumurthy Hiremath, John E Mayer and 2 more

Abstract read
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In one paragraph

Article in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Cyclic stretch inhibits cell invasion in 3D scaffolds.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeeshan H SyedainDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Matthew LahtiExperimental Surgical Services, University of Minnesota, Minneapolis, MN 55455, USA.
James BerryExperimental Surgical Services, University of Minnesota, Minneapolis, MN 55455, USA.
John P CarneyExperimental Surgical Services, University of Minnesota, Minneapolis, MN 55455, USA.
Jill Schappa FaustichVeterinary Clinical Sciences Department, University of Minnesota, Minneapolis, MN 55455, USA.
Bee Haynie
Jack MaherDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Richard BiancoExperimental Surgical Services, University of Minnesota, Minneapolis, MN 55455, USA.
Gurumurthy HiremathDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
John E MayerBoston Children's Hospital and Department of Thoracic Surgery, Harvard Medical School, Boston, MA, USA.
Robroy MacIverChildren's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA.
Robert T TranquilloDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4668-6135

Funding

Tissue-engineered pulmonic valve grown from human cells for pediatric patientsR01HL107572 · NHLBI · UNIVERSITY OF MINNESOTA · PI TRANQUILLO, ROBERT T · 2011 to 2021
$6.2M
NHLBI NIH HHS R01 HL107572NIH HHS R01 HL107572
6 · The paper itself

Abstract

aimsReplacement heart valves that grow with children remain an unmet need. We previously reported valves fabricated from tubes of fibroblast-derived collagenous matrix increased in size while functioning with low systolic gradients and less than moderate regurgitation over 52 weeks in most cases, when implanted as interpositional grafts in the pulmonary artery of lambs. Here, we evaluated valved conduits fabricated by including an inflow segment to the tri-tube valve allowing for myocardial anastomosis as done in a typical right ventricular outflow tract (RVOT) surgical repair, in the same growing lamb model. METHODS AND

resultsIn this pilot study, 19 mm valved conduits fabricated from resorbable suture were implanted into Dorset lambs (n = 3), sutured to the pulmonary annulus and distal pulmonary artery with resorbable suture after dissection of the pulmonary valve leaflets and resection of an arterial segment. Valve function and dimensions were measured with longitudinal transthoracic echocardiography. All animals exhibited an increase in valve diameter (18.2 ± 1.8 mm at 1 week to 25.1 ± 2.4 mm at 52 weeks) and leaflet free-edge length (21.1 ± 2.4 mm at 1 week to 26.2 ± 3.9 mm at 52 weeks) while functioning with at most mild regurgitation over 52 weeks. The inflow segment of the conduit grew somatically based on its unchanged thickness and increased diameter (38%) and collagen content (128%). In all three explanted conduits, the leaflets contained interstitial cells, new collagen and elastin primarily around the base, a developing endothelium on the surfaces, and they remained thin and pliable without macroscopic calcification. There was interdigitating integration of the conduit with the myocardium at the pulmonary annulus. Further, a stent was successfully placed in a valved conduit at term to evaluate feasibility of a prospective clinical intervention.

conclusionThis valved conduit grows in lambs based on this pilot study and thus has clinical potential for RVOT reconstruction and long-term valve growth in children.

Indexed as

BioprosthesisHeart Valve ProsthesisHeart Valve Prosthesis ImplantationPulmonary ValveTissue EngineeringAbsorbable ImplantsAnimalsHemodynamicsModels, AnimalPilot ProjectsProsthesis DesignPulmonary ArterySheepSheep, DomesticTime FactorsVentricular Function, RightPulmonary conduitRegenerationTetralogy of FallotTissue engineeringValved conduit

Identifiers

PMID40105211
PMCPMC13017468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.