Evidence map›Paper›PMID 40105119›Full record

ArticleAJOB empirical bioethics

Is It a Bribe? Research Personnels' Perceptions of the Ethical Aspects of Financial Compensation to Healthy Volunteers in Prevention Trials in Tanzania.

Raymond Athanas, Gasto Frumence, Rebecca J DeBoer, Connie M Ulrich

Abstract read
In one paragraph

Article in AJOB empirical bioethics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raymond AthanasDepartment of Bioethics and Health Professionalism, School of Public Health, Muhimbili University of health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0002-4655-2279
Gasto FrumenceDepartment of Bioethics and Health Professionalism, School of Public Health, Muhimbili University of health and Allied Sciences, Dar es Salaam, Tanzania.
Rebecca J DeBoerDivision of Hematology/Oncology, University of California San Francisco, San Francisco, California, USA.
Connie M UlrichBiobehavioral Department, School of Nursing, University of Pennsylvania School of Nursing, Pennsylvania, Philadelphia, USA.ORCID 0000-0001-5681-3463

Funding

Educating and Developing Bioethicists in Tanzania (ENGAGE)D43TW011809 · FIC · UNIVERSITY OF PENNSYLVANIA · PI ULRICH, CONNIE MARIE · 2021 to 2025
$1.4M
Validation of Quality Measures for Patient-Centered Cancer Communication in RwandaK08CA279874 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rebecca DeBoer · 2024 to 2026
$805k
FIC NIH HHS D43 TW011809NCI NIH HHS K08 CA279874
6 · The paper itself

Abstract

backgroundFinancial compensation may be perceived as a catalyst to increase the recruitment and retention of healthy volunteers in clinical trials but also potentially as a form of undue inducement. The ethical guidelines in Tanzania, while helpful, are not clear on what is considered reasonable compensation for healthy volunteers and the extent to which it influences participation. This study aimed to explore research personnels' perceptions of the ethical aspects of financial compensation to healthy volunteers participating in prevention trials in Tanzania.

methodsQualitative semi-structured interviews were conducted in Tanzania with a purposive sample of 36 research personnel with different project roles ranging from principal investigators (PIs) to study staff on six prevention trials. The interviews were recorded and transcribed verbatim and thematic analysis was performed.

resultsMost research personnel were physicians (64%) and male (67%) with a mean age of 48 years. Three qualitative themes were identified: ethical justifications for financial compensation, ethical concerns about financial compensation and fair compensation as income. Most Tanzanian research personnel were more aligned with the view that financial compensation is an ethical responsibility in respecting the value of a healthy volunteer's time and effort, especially for those who face barriers to participation, rather than being a bribe. However, there were those who raised ethical concerns about financial compensation that included perceptions of bribing low-income earners and increased misperceptions of trial activities. Research personnel also indicated that the specific amount of financial compensation has ethical implications. Amounts that were either too much or too little were viewed as unethical, whereas a modest rate was perceived as ethical.

conclusionsPaying healthy volunteers is a measure of respect and supported by the national Tanzanian research guidelines. However, a reevaluation of these research ethical guidelines to redefine reasonable, fair and just financial compensation, especially for those who face significant barriers to participation, would continue to respect healthy volunteers and provide regional guidance for researchers within the country.

Indexed as

Clinical Trials as TopicCompensation and RedressHealthy VolunteersPatient SelectionResearch PersonnelAdultEthics, ResearchFemaleHumansMaleMiddle AgedMotivationQualitative ResearchTanzaniaethicsFinancial compensationprevention trialsrespectTanzania

Identifiers

PMID40105119
PMCPMC12806150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.