ArticleAndrology2026
Normozoospermic men in infertile couples: Potential benefit of early medical diagnostic procedures.
Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Optimizing family building in women of advanced reproductive age: a Faster-Fewer-and-Finished approach.Frontiers in endocrinology · 2026Review
- Normozoospermic men in infertile couples: Potential benefit of early medical diagnostic procedures.Andrology · 2026Article
- Determinants of male fertility in the Western Pacific Region: environmental, biological, and lifestyle influences.The Lancet regional health. Western Pacific · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
introductionInfertility, defined as the inability to achieve pregnancy despite regular, unprotected sexual intercourse for 1 year, affects approximately 15% of couples. Male factors contribute to 50% of these cases. The necessity of andrological evaluations for male partners of infertile couples with normozoospermia is currently under consideration.
methodsFrom 2010 to 2020, our center evaluated 997 patients presenting with infertility and normozoospermia. All patients underwent comprehensive assessments, including physical examinations, testicular sonography, blood tests, follice-stimulating hormone beta (FSHB) c.-211 variants, and semen analyses. For comparative purposes, we established two control groups: one comprising healthy men participating in the FAMe study (n = 201) and another consisting of men seeking fertility restoration following vasectomy (n = 75). Within the infertile male group, we further stratified patients into those with primary or secondary infertility.
resultsAnalysis of patient histories revealed a significantly elevated prevalence of genital malformations (e.g., hypospadias (p = 0.024) and undescended testes during childhood (p < 0.001) in our infertile group relative to the control group. By anamnesis we could find significant more patients with erectile dysfunction (p < 0.001) in our infertile men. The physical examination showed significant more patients with obesity in our infertility group (p < 0.001). Regarding hormonal profiles, a notably higher proportion of patients in the infertility group exhibited hypogonadism (p < 0.001), while compensated hypogonadism was more common in the control group. Reduced serum follicle-stimulating hormone (FSH) concentrations in men with the FSHB c.-211 GT/TT polymorphism versus the GG wildtype were only present in the infertile but not the fertile cohort (p < 0.001). Evaluation of ejaculate samples indicated a significant increase in round cells (p < 0.001) and leukocytes (p = 0.013) in our infertile patients compared to the healthy subjects. DISCUSSION: The assessment of men presenting with infertility and normozoospermia unveiled a marked prevalence of physical and genetic findings. This underscores the critical need for andrological evaluations to prevent potential long-term consequences.
conclusionThe andrological examination of normozoospermic and infertile men promises better health outcomes for the patients as well as it aids in refining fertility treatment options for their female counterparts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.