Evidence map›Paper›PMID 40105013›Full record

ArticleGlia2025

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice.

Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos

Abstract read
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In one paragraph

Article in Glia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dying oligodendrocytes persist without mitochondria.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Niki KtenaSchool of Medicine, University of Crete, Heraklion, Greece.ORCID 0000-0001-8308-3646
Dimitrios SpyridakosSchool of Medicine, University of Crete, Heraklion, Greece.
Alexandros GeorgilisSchool of Medicine, University of Crete, Heraklion, Greece.
Ilias KalafatakisSchool of Medicine, University of Crete, Heraklion, Greece.
Efstathia ThomoglouSchool of Medicine, University of Crete, Heraklion, Greece.
Angeliki KolaxiDepartment of Fundamental Neurosciences (DNF), University of Lausanne, Lausanne, Switzerland.
Vassiliki NikoletopoulouDepartment of Fundamental Neurosciences (DNF), University of Lausanne, Lausanne, Switzerland.
Maria SavvakiSchool of Medicine, University of Crete, Heraklion, Greece.ORCID 0000-0001-9094-1055
Domna KaragogeosSchool of Medicine, University of Crete, Heraklion, Greece.ORCID 0000-0002-8129-9731

Funding

European Union-Next Generation EU TAEDR 0535850Hellenic Academy of Neuroimmunology (HELANI)Hellenic Foundation for Research and Innovation (HFRI) 014772Hellenic Foundation for Research and Innovation (HFRI) 1676Manassaki Fellowship, University of CreteNational Multiple Sclerosis Society PP-1809-32556State Scholarships Foundation MIS-5113934
6 · The paper itself

Abstract

The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms remain elusive. This study delves into the previously unexplored role of autophagy in maintaining CNS myelin during aging. We generated the transgenic mouse line plpCre

Indexed as

AgingApoptosisAutophagyCognitive DysfunctionMyelin SheathNeuronsOligodendrogliaAnimalsAutophagy-Related Protein 5AxonsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicAtg5 protein, mouseAutophagy-Related Protein 5agingautophagyCNSmyelinneurodegeneration

Identifiers

PMID40105013
PMCPMC12121467

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.